Cargando…

The impact of mutational clonality in predicting the response to immune checkpoint inhibitors in advanced urothelial cancer

Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment and can result in complete remissions even at advanced stages of the disease. However, only a small fraction of patients respond to the treatment. To better understand which factors drive clinical benefit, we have generated whol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boll, Lilian Marie, Perera-Bel, Júlia, Rodriguez-Vida, Alejo, Arpí, Oriol, Rovira, Ana, Juanpere, Núria, Vázquez Montes de Oca, Sergio, Hernández-Llodrà, Silvia, Lloreta, Josep, Albà, M. Mar, Bellmunt, Joaquim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504302/ https://www.ncbi.nlm.nih.gov/pubmed/37714872 http://dx.doi.org/10.1038/s41598-023-42495-2

Ejemplares similares

Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer
por: Bowden, Michaela, et al.
Publicado: (2020)

ERG overexpression plus SLC45A3 (prostein) and PTEN expression loss: Strong association of the triple hit phenotype with an aggressive pathway of prostate cancer progression
por: Hernández-Llodrà, Silvia, et al.
Publicado: (2017)

Urothelial carcinoma management in elderly or unfit patients()
por: Bellmunt, Joaquim, et al.
Publicado: (2016)

New treatment options for metastatic renal cell carcinoma
por: Rodriguez-Vida, Alejo, et al.
Publicado: (2017)

Correction: Effect of Insulin on ACE2 Activity and Kidney Function in the Non-Obese Diabetic Mouse
por: Riera, Marta, et al.
Publicado: (2014)

Effect of Insulin on ACE2 Activity and Kidney Function in the Non-Obese Diabetic Mouse
por: Riera, Marta, et al.
Publicado: (2014)

Epithelial-to-Mesenchymal Transition Mediates Resistance to Maintenance Therapy with Vinflunine in Advanced Urothelial Cell Carcinoma
por: Font, Albert, et al.
Publicado: (2021)

Upper tract urothelial carcinoma: a different disease entity in terms of management
por: Leow, Jeffrey J, et al.
Publicado: (2017)

Contribution of Human papillomavirus in neuroendocrine tumors from a series of 10,575 invasive cervical cancer cases
por: Alejo, Maria, et al.
Publicado: (2018)

ARID1A Alterations Are Associated with FGFR3-Wild Type, Poor-Prognosis, Urothelial Bladder Tumors
por: Balbás-Martínez, Cristina, et al.
Publicado: (2013)

Correction: ARID1A Alterations Are Associated with FGFR3-Wild Type, Poor-Prognosis, Urothelial Bladder Tumors
por: Balbás-Martínez, Cristina, et al.
Publicado: (2014)

Discovering the drivers of clonal hematopoiesis
por: Pich, Oriol, et al.
Publicado: (2022)

The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder
por: van Doeveren, Thomas, et al.
Publicado: (2020)

Atezolizumab in patients with renal insufficiency and mixed variant histology: analyses from an expanded access program in platinum-treated locally advanced or metastatic urothelial carcinoma
por: Hoffman-Censits, Jean, et al.
Publicado: (2020)

Complexity of FGFR signalling in metastatic urothelial cancer
por: Rodriguez-Vida, Alejo, et al.
Publicado: (2015)

Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma
por: Mullane, Stephanie A., et al.
Publicado: (2016)

Mutational signature and clonal relatedness of recurrent urothelial carcinomas with aristolochic acid
por: Zhu, Jie, et al.
Publicado: (2022)

Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes
por: Michel-Todó, Lucas, et al.
Publicado: (2022)

A Case Report Demonstrating the Potential Clinical Benefit of Exhaustive Molecular Profiling in an Aggressive Muscle-Invasive High-Grade Metastatic Urothelial Carcinoma
por: Ramírez de Olano, Amaya, et al.
Publicado: (2017)

Immunotherapy With Checkpoint Inhibitors in FGFR-Altered Urothelial Carcinoma
por: Benjamin, David J, et al.
Publicado: (2022)

Comparison of the clonality of urothelial carcinoma developing in the upper urinary tract and those developing in the bladder
por: Wang, Yuding, et al.
Publicado: (2013)

Identification of ALK Gene Alterations in Urothelial Carcinoma
por: Bellmunt, Joaquim, et al.
Publicado: (2014)

Stem-Like Signature Predicting Disease Progression in Early Stage Bladder Cancer. The Role of E2F3 and SOX4
por: Bellmunt, Joaquim
Publicado: (2018)

DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors
por: Bambury, Richard M, et al.
Publicado: (2015)

HER2 as a target in invasive urothelial carcinoma
por: Bellmunt, Joaquim, et al.
Publicado: (2015)

Clonal, Self-Renewing and Differentiating Human and Porcine Urothelial Cells, a Novel Stem Cell Population
por: Larsson, Hans M., et al.
Publicado: (2014)

Cyclooxygenase-2 Expression in Bladder Cancer and Patient Prognosis: Results from a Large Clinical Cohort and Meta-Analysis
por: Czachorowski, Maciej J., et al.
Publicado: (2012)

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancer
por: Dalmases, Alba, et al.
Publicado: (2013)

Everolimus and pazopanib (E/P) benefit genomically selected patients with metastatic urothelial carcinoma
por: Bellmunt, Joaquim, et al.
Publicado: (2018)

Paraneoplastic dermatomyositis associated with urothelial cancer: report of a case and systematic review of the literature
por: Sabaté-Ortega, Josep, et al.
Publicado: (2023)

FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder
por: Guancial, Elizabeth A, et al.
Publicado: (2014)

The impact of prior platinum therapy on survival in patients with metastatic urothelial cancer receiving vinflunine
por: Harshman, L C, et al.
Publicado: (2013)

Treatments Outcomes in Histological Variants and Non-Urothelial Bladder Cancer: Results of a Multicenter Retrospective Study
por: Epaillard, Nicolas, et al.
Publicado: (2021)

Association of tumour microRNA profiling with outcomes in patients with advanced urothelial carcinoma receiving first-line platinum-based chemotherapy
por: Bellmunt, Joaquim, et al.
Publicado: (2016)

Pembrolizumab versus chemotherapy in recurrent, advanced urothelial cancer in Japanese patients: a subgroup analysis of the phase 3 KEYNOTE-045 trial
por: Nishiyama, Hiroyuki, et al.
Publicado: (2019)

Clonal analysis of lineage fate in native hematopoiesis
por: Rodriguez-Fraticelli, Alejo E., et al.
Publicado: (2018)

A Comparison of RNA-Seq Results from Paired Formalin-Fixed Paraffin-Embedded and Fresh-Frozen Glioblastoma Tissue Samples
por: Esteve-Codina, Anna, et al.
Publicado: (2017)

Immune checkpoint inhibitors for urothelial carcinoma
por: Kim, Hyung Suk, et al.
Publicado: (2018)

Imaging of breast implants—a pictorial review
por: Juanpere, Sergi, et al.
Publicado: (2011)

Metastatic urothelial carcinoma presenting as acute cholecystitis
por: Ling, Xing Yao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4l3clpu47d1lh2hkd0og36chdb