Unraveling the mechanisms underlying drug-induced cholestatic liver injury: identifying key genes using machine learning techniques on human in vitro data sets

Drug-induced intrahepatic cholestasis (DIC) is a main type of hepatic toxicity that is challenging to predict in early drug development stages. Preclinical animal studies often fail to detect DIC in humans. In vitro toxicogenomics assays using human liver cells have become a practical approach to pr...

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Detalles Bibliográficos
Autores principales: Jiang, Jian, van Ertvelde, Jonas, Ertaylan, Gökhan, Peeters, Ralf, Jennen, Danyel, de Kok, Theo M., Vinken, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504391/
https://www.ncbi.nlm.nih.gov/pubmed/37603094
http://dx.doi.org/10.1007/s00204-023-03583-4

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