Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis

Calcific aortic valve stenosis (CAVS) is a widespread valvular heart disease affecting people in aging societies, primarily characterized by fibrosis, inflammation, and progressive calcification, leading to valve orifice stenosis. Understanding the factors associated with CAVS onset and progression...

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Detalles Bibliográficos
Autores principales: Anousakis-Vlachochristou, Nikolaos, Athanasiadou, Dimitra, Carneiro, Karina M.M., Toutouzas, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
State-of-the-Art Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504402/
https://www.ncbi.nlm.nih.gov/pubmed/37719438
http://dx.doi.org/10.1016/j.jacbts.2023.01.009
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author Anousakis-Vlachochristou, Nikolaos
Athanasiadou, Dimitra
Carneiro, Karina M.M.
Toutouzas, Konstantinos
author_facet Anousakis-Vlachochristou, Nikolaos
Athanasiadou, Dimitra
Carneiro, Karina M.M.
Toutouzas, Konstantinos
author_sort Anousakis-Vlachochristou, Nikolaos
collection PubMed
description Calcific aortic valve stenosis (CAVS) is a widespread valvular heart disease affecting people in aging societies, primarily characterized by fibrosis, inflammation, and progressive calcification, leading to valve orifice stenosis. Understanding the factors associated with CAVS onset and progression is crucial to develop effective future pharmaceutical therapies. In CAVS, native extracellular matrix proteins modifications, play a significant role in calcification in vitro and in vivo. This work aimed to review the evidence on the alterations of structural native extracellular matrix proteins involved in calcification development during CAVS and highlight its link to deregulated biomechanical function.
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spelling pubmed-105044022023-09-17 Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis Anousakis-Vlachochristou, Nikolaos Athanasiadou, Dimitra Carneiro, Karina M.M. Toutouzas, Konstantinos JACC Basic Transl Sci State-of-the-Art Review Calcific aortic valve stenosis (CAVS) is a widespread valvular heart disease affecting people in aging societies, primarily characterized by fibrosis, inflammation, and progressive calcification, leading to valve orifice stenosis. Understanding the factors associated with CAVS onset and progression is crucial to develop effective future pharmaceutical therapies. In CAVS, native extracellular matrix proteins modifications, play a significant role in calcification in vitro and in vivo. This work aimed to review the evidence on the alterations of structural native extracellular matrix proteins involved in calcification development during CAVS and highlight its link to deregulated biomechanical function. Elsevier 2023-03-29 /pmc/articles/PMC10504402/ /pubmed/37719438 http://dx.doi.org/10.1016/j.jacbts.2023.01.009 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle State-of-the-Art Review
Anousakis-Vlachochristou, Nikolaos
Athanasiadou, Dimitra
Carneiro, Karina M.M.
Toutouzas, Konstantinos
Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis
title Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis
title_full Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis
title_fullStr Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis
title_full_unstemmed Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis
title_short Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis
title_sort focusing on the native matrix proteins in calcific aortic valve stenosis
topic State-of-the-Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504402/
https://www.ncbi.nlm.nih.gov/pubmed/37719438
http://dx.doi.org/10.1016/j.jacbts.2023.01.009
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