Rapid changes of mRNA expressions of cardiac ion channels affected by Torsadogenic drugs influence susceptibility of rat hearts to arrhythmias induced by Beta‐Adrenergic stimulation

Drug‐induced long QT syndrome (LQTS) and Torsades de Pointes (TdP) are serious concerns in drug development. Although rats are a useful scientific tool, their hearts, unlike larger species, usually do not respond to torsadogenic drugs. Consequently, their resistance to drug‐induced arrhythmias is po...

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Detalles Bibliográficos
Autores principales: Hadova, Katarina, Kmecova, Jana, Ochodnicka‐Mackovicova, Katarina, Kralova, Eva, Doka, Gabriel, Bies Pivackova, Lenka, Vavrinec, Peter, Stankovicova, Tatiana, Krenek, Peter, Klimas, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504435/
https://www.ncbi.nlm.nih.gov/pubmed/37715323
http://dx.doi.org/10.1002/prp2.1134

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