Squamous cell carcinoma of the neovagina 47 years after gender-affirming surgery

A 74-year-old transgender female presented with urinary difficulty and a painful lesion at her neo-vagina, 47 years after undergoing gender-affirming vaginoplasty. Initial biopsy reported Low-Grade Squamous Intraepithelial Lesion (LGSIL), while MRI revealed no inguinal or pelvic lymphadenopathy. Pat...

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Detalles Bibliográficos
Autores principales: Arruza-Frau, Cristina, López-García, Ariana, Morales-López, Ramphis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Trauma and Reconstruction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504474/
https://www.ncbi.nlm.nih.gov/pubmed/37719184
http://dx.doi.org/10.1016/j.eucr.2023.102488
Descripción
Sumario:A 74-year-old transgender female presented with urinary difficulty and a painful lesion at her neo-vagina, 47 years after undergoing gender-affirming vaginoplasty. Initial biopsy reported Low-Grade Squamous Intraepithelial Lesion (LGSIL), while MRI revealed no inguinal or pelvic lymphadenopathy. Patient underwent partial neo-vaginectomy with wide local excision and formal urethroplasty. Pathology revealed verrucous carcinoma of the neovagina, a rare neoplasm in transgender female patients. This case highlights the importance of considering squamous cell carcinoma in the differential diagnosis of patients presenting lesions at neo-vagina and the need of screening methods for early detection of such neoplasms.

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