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In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines

The medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast...

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Autores principales: Sabu, Abraham, J, Selvaraj, R, Gayatridevi, E, Dilipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504496/
https://www.ncbi.nlm.nih.gov/pubmed/37720282
http://dx.doi.org/10.6026/97320630019043
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author Sabu, Abraham
J, Selvaraj
R, Gayatridevi
E, Dilipan
author_facet Sabu, Abraham
J, Selvaraj
R, Gayatridevi
E, Dilipan
author_sort Sabu, Abraham
collection PubMed
description The medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast cancer cell lines. Because of this, its anticancer effect may be caused by apoptosis, which is caused by DNA breaking and is helped by active phytochemicals like alkaloids, phenols, and flavonoids in the extracts. It also promotes apoptosis by altering Bcl-2 and TGF expression levels. The present study suggests using R. tetraphylla extract as an anticancer agent in traditional medicine.
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spelling pubmed-105044962023-09-17 In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines Sabu, Abraham J, Selvaraj R, Gayatridevi E, Dilipan Bioinformation Research Article The medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast cancer cell lines. Because of this, its anticancer effect may be caused by apoptosis, which is caused by DNA breaking and is helped by active phytochemicals like alkaloids, phenols, and flavonoids in the extracts. It also promotes apoptosis by altering Bcl-2 and TGF expression levels. The present study suggests using R. tetraphylla extract as an anticancer agent in traditional medicine. Biomedical Informatics 2023-01-31 /pmc/articles/PMC10504496/ /pubmed/37720282 http://dx.doi.org/10.6026/97320630019043 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Sabu, Abraham
J, Selvaraj
R, Gayatridevi
E, Dilipan
In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
title In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
title_full In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
title_fullStr In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
title_full_unstemmed In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
title_short In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
title_sort in-vitro anticancer activity of rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504496/
https://www.ncbi.nlm.nih.gov/pubmed/37720282
http://dx.doi.org/10.6026/97320630019043
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