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In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
The medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Biomedical Informatics
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504496/ https://www.ncbi.nlm.nih.gov/pubmed/37720282 http://dx.doi.org/10.6026/97320630019043 |
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author | Sabu, Abraham J, Selvaraj R, Gayatridevi E, Dilipan |
author_facet | Sabu, Abraham J, Selvaraj R, Gayatridevi E, Dilipan |
author_sort | Sabu, Abraham |
collection | PubMed |
description | The medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast cancer cell lines. Because of this, its anticancer effect may be caused by apoptosis, which is caused by DNA breaking and is helped by active phytochemicals like alkaloids, phenols, and flavonoids in the extracts. It also promotes apoptosis by altering Bcl-2 and TGF expression levels. The present study suggests using R. tetraphylla extract as an anticancer agent in traditional medicine. |
format | Online Article Text |
id | pubmed-10504496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-105044962023-09-17 In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines Sabu, Abraham J, Selvaraj R, Gayatridevi E, Dilipan Bioinformation Research Article The medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast cancer cell lines. Because of this, its anticancer effect may be caused by apoptosis, which is caused by DNA breaking and is helped by active phytochemicals like alkaloids, phenols, and flavonoids in the extracts. It also promotes apoptosis by altering Bcl-2 and TGF expression levels. The present study suggests using R. tetraphylla extract as an anticancer agent in traditional medicine. Biomedical Informatics 2023-01-31 /pmc/articles/PMC10504496/ /pubmed/37720282 http://dx.doi.org/10.6026/97320630019043 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Research Article Sabu, Abraham J, Selvaraj R, Gayatridevi E, Dilipan In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines |
title | In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines |
title_full | In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines |
title_fullStr | In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines |
title_full_unstemmed | In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines |
title_short | In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines |
title_sort | in-vitro anticancer activity of rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504496/ https://www.ncbi.nlm.nih.gov/pubmed/37720282 http://dx.doi.org/10.6026/97320630019043 |
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