Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds

Beta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Ta...

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Autores principales: Sharma, Vipra, Rengasamy, Gayathri, Sekaran, Surya, Sankaran, Kavitha, Veeraraghavan, Vishnu Priya, Eswaramoorthy, Rajalakshmanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504516/
https://www.ncbi.nlm.nih.gov/pubmed/37720289
http://dx.doi.org/10.6026/97320630019111
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author Sharma, Vipra
Rengasamy, Gayathri
Sekaran, Surya
Sankaran, Kavitha
Veeraraghavan, Vishnu Priya
Eswaramoorthy, Rajalakshmanan
author_facet Sharma, Vipra
Rengasamy, Gayathri
Sekaran, Surya
Sankaran, Kavitha
Veeraraghavan, Vishnu Priya
Eswaramoorthy, Rajalakshmanan
author_sort Sharma, Vipra
collection PubMed
description Beta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Tamoxifen used as control. Data shows that compounds 2, 4, and 6 exhibited comparably significant molecular interactions with the cancerous protein for further consideration.
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spelling pubmed-105045162023-09-17 Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds Sharma, Vipra Rengasamy, Gayathri Sekaran, Surya Sankaran, Kavitha Veeraraghavan, Vishnu Priya Eswaramoorthy, Rajalakshmanan Bioinformation Research Article Beta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Tamoxifen used as control. Data shows that compounds 2, 4, and 6 exhibited comparably significant molecular interactions with the cancerous protein for further consideration. Biomedical Informatics 2023-01-31 /pmc/articles/PMC10504516/ /pubmed/37720289 http://dx.doi.org/10.6026/97320630019111 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Sharma, Vipra
Rengasamy, Gayathri
Sekaran, Surya
Sankaran, Kavitha
Veeraraghavan, Vishnu Priya
Eswaramoorthy, Rajalakshmanan
Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds
title Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds
title_full Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds
title_fullStr Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds
title_full_unstemmed Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds
title_short Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds
title_sort molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504516/
https://www.ncbi.nlm.nih.gov/pubmed/37720289
http://dx.doi.org/10.6026/97320630019111
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