Cas4/1 dual nuclease activities enable prespacer maturation and directional integration in a type I-G CRISPR-Cas system

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CRISPR-Cas adaptive immune systems uptake short “spacer” sequences from foreign DNA and incorporate them into the host genome to serve as templates for CRISPR RNAs that guide interference against future infections. Adaptation in CRISPR systems is mediated by Cas1-Cas2 complexes that catalyze integra...

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Detalles Bibliográficos
Autores principales: Dhingra, Yukti, Sashital, Dipali G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504553/
https://www.ncbi.nlm.nih.gov/pubmed/37607619
http://dx.doi.org/10.1016/j.jbc.2023.105178

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