SHP-1 phosphatase acts as a coactivator of PCK1 transcription to control gluconeogenesis

We previously reported that the protein-tyrosine phosphatase SHP-1 (PTPN6) negatively regulates insulin signaling, but its impact on hepatic glucose metabolism and systemic glucose control remains poorly understood. Here, we use co-immunoprecipitation assays, chromatin immunoprecipitation sequencing...

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Detalles Bibliográficos
Autores principales: Kumar, Amit, Schwab, Michael, Laborit Labrada, Beisy, Silveira, Maruhen Amir Datsch, Goudreault, Marilyn, Fournier, Éric, Bellmann, Kerstin, Beauchemin, Nicole, Gingras, Anne-Claude, Bilodeau, Steve, Laplante, Mathieu, Marette, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504565/
https://www.ncbi.nlm.nih.gov/pubmed/37595871
http://dx.doi.org/10.1016/j.jbc.2023.105164

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