Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons

The mechanistic tie between genome-wide association study (GWAS)-implicated risk variants and disease-relevant cellular phenotypes remains largely unknown. Here, using human induced pluripotent stem cell (hiPSC)-derived neurons as a neurodevelopmental model, we identify multiple schizophrenia (SZ) r...

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Detalles Bibliográficos
Autores principales: Zhang, Siwei, Zhang, Hanwen, Forrest, Marc P., Zhou, Yifan, Sun, Xiaotong, Bagchi, Vikram A., Kozlova, Alena, Santos, Marc Dos, Piguel, Nicolas H., Dionisio, Leonardo E., Sanders, Alan R., Pang, Zhiping P., He, Xin, Penzes, Peter, Duan, Jubao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504676/
https://www.ncbi.nlm.nih.gov/pubmed/37719141
http://dx.doi.org/10.1016/j.xgen.2023.100399

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