Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages

BACKGROUND: The intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, brain tissue remodeling, and neurological recovery in young, healthy stroke mice. However, the translation of cell-based therapies to clinical settings has encountere...

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Detalles Bibliográficos
Autores principales: Yin, Dongpei, Wang, Chen, Qi, Yachao, Wang, Ya-Chao, Hagemann, Nina, Mohamud Yusuf, Ayan, Dzyubenko, Egor, Kaltwasser, Britta, Tertel, Tobias, Giebel, Bernd, Gunzer, Matthias, Popa-Wagner, Aurel, Doeppner, Thorsten R., Hermann, Dirk M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504699/
https://www.ncbi.nlm.nih.gov/pubmed/37715288
http://dx.doi.org/10.1186/s12974-023-02894-8

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