Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis

The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue, we examined the cellular origin and progression of AD pathog...

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Detalles Bibliográficos
Autores principales: Pomeshchik, Yuriy, Velasquez, Erika, Gil, Jeovanis, Klementieva, Oxana, Gidlöf, Ritha, Sydoff, Marie, Bagnoli, Silvia, Nacmias, Benedetta, Sorbi, Sandro, Westergren-Thorsson, Gunilla, Gouras, Gunnar K., Rezeli, Melinda, Roybon, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504768/
https://www.ncbi.nlm.nih.gov/pubmed/37715247
http://dx.doi.org/10.1186/s40478-023-01649-z

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