Handling intercurrent events and missing data in non-inferiority trials using the estimand framework: A tuberculosis case study

INTRODUCTION: The ICH E9 addendum outlining the estimand framework for clinical trials was published in 2019 but provides limited guidance around how to handle intercurrent events for non-inferiority studies. Once an estimand is defined, it is also unclear how to deal with missing values using princ...

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Detalles Bibliográficos
Autores principales: Rehal, Sunita, Cro, Suzie, Phillips, Patrick PJ, Fielding, Katherine, Carpenter, James R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504812/
https://www.ncbi.nlm.nih.gov/pubmed/37277978
http://dx.doi.org/10.1177/17407745231176773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504812/
https://www.ncbi.nlm.nih.gov/pubmed/37277978
http://dx.doi.org/10.1177/17407745231176773

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