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3D bioprinting of corneal models: A review of the current state and future outlook

The cornea is the outermost layer of the eye and serves to protect the eye and enable vision by refracting light. The need for cornea organ donors remains high, and the demand for an artificial alternative continues to grow. 3D bioprinting is a promising new method to create artificial organs and ti...

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Detalles Bibliográficos
Autores principales: Balters, Leon, Reichl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504850/
https://www.ncbi.nlm.nih.gov/pubmed/37719307
http://dx.doi.org/10.1177/20417314231197793
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author Balters, Leon
Reichl, Stephan
author_facet Balters, Leon
Reichl, Stephan
author_sort Balters, Leon
collection PubMed
description The cornea is the outermost layer of the eye and serves to protect the eye and enable vision by refracting light. The need for cornea organ donors remains high, and the demand for an artificial alternative continues to grow. 3D bioprinting is a promising new method to create artificial organs and tissues. 3D bioprinting offers the precise spatial arrangement of biomaterials and cells to create 3D constructs. As the cornea is an avascular tissue which makes it more attractive for 3D bioprinting, it could be one of the first tissues to be made fully functional via 3D bioprinting. This review discusses the most common 3D bioprinting technologies and biomaterials used for 3D bioprinting corneal models. Additionally, the current state of 3D bioprinted corneal models, especially specific characteristics such as light transmission, biomechanics, and marker expression, and in vivo studies are discussed. Finally, the current challenges and future prospects are presented.
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spelling pubmed-105048502023-09-17 3D bioprinting of corneal models: A review of the current state and future outlook Balters, Leon Reichl, Stephan J Tissue Eng Design and Manufacture of Tissue Engineered Products Using Additive Manufacturing Techniques The cornea is the outermost layer of the eye and serves to protect the eye and enable vision by refracting light. The need for cornea organ donors remains high, and the demand for an artificial alternative continues to grow. 3D bioprinting is a promising new method to create artificial organs and tissues. 3D bioprinting offers the precise spatial arrangement of biomaterials and cells to create 3D constructs. As the cornea is an avascular tissue which makes it more attractive for 3D bioprinting, it could be one of the first tissues to be made fully functional via 3D bioprinting. This review discusses the most common 3D bioprinting technologies and biomaterials used for 3D bioprinting corneal models. Additionally, the current state of 3D bioprinted corneal models, especially specific characteristics such as light transmission, biomechanics, and marker expression, and in vivo studies are discussed. Finally, the current challenges and future prospects are presented. SAGE Publications 2023-09-15 /pmc/articles/PMC10504850/ /pubmed/37719307 http://dx.doi.org/10.1177/20417314231197793 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Design and Manufacture of Tissue Engineered Products Using Additive Manufacturing Techniques
Balters, Leon
Reichl, Stephan
3D bioprinting of corneal models: A review of the current state and future outlook
title 3D bioprinting of corneal models: A review of the current state and future outlook
title_full 3D bioprinting of corneal models: A review of the current state and future outlook
title_fullStr 3D bioprinting of corneal models: A review of the current state and future outlook
title_full_unstemmed 3D bioprinting of corneal models: A review of the current state and future outlook
title_short 3D bioprinting of corneal models: A review of the current state and future outlook
title_sort 3d bioprinting of corneal models: a review of the current state and future outlook
topic Design and Manufacture of Tissue Engineered Products Using Additive Manufacturing Techniques
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504850/
https://www.ncbi.nlm.nih.gov/pubmed/37719307
http://dx.doi.org/10.1177/20417314231197793
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