Cargando…
Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis
[Objective] Few studies have comprehensively investigated the non-motor symptoms of amyotrophic lateral sclerosis (ALS). We aimed to investigate this aspect of ALS. [Methods] We held a nationwide webinar, titled “ALS Café,” and distributed self-report questionnaires to ALS patients. In addition to t...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505101/ https://www.ncbi.nlm.nih.gov/pubmed/35987973 http://dx.doi.org/10.1007/s13760-022-02036-6 |
_version_ | 1785106847080906752 |
---|---|
author | Hirayama, Takehisa Shibukawa, Mari Yanagihashi, Masaru Warita, Hitoshi Atsuta, Naoki Yamanaka, Koji Kano, Osamu |
author_facet | Hirayama, Takehisa Shibukawa, Mari Yanagihashi, Masaru Warita, Hitoshi Atsuta, Naoki Yamanaka, Koji Kano, Osamu |
author_sort | Hirayama, Takehisa |
collection | PubMed |
description | [Objective] Few studies have comprehensively investigated the non-motor symptoms of amyotrophic lateral sclerosis (ALS). We aimed to investigate this aspect of ALS. [Methods] We held a nationwide webinar, titled “ALS Café,” and distributed self-report questionnaires to ALS patients. In addition to the frequency of non-motor symptoms such as fatigue, pain, sleep disorders, defecation disorders, sialorrhea, and sexual problems, we evaluated the quality of life (QoL), ALS Functional Rating Scale-Revised (ALSFRS-R), and Patient Health Questionnaire-9 (PHQ-9). [Results] The average age of the 33 respondents (19 male, 14 female) was 60.8 ± 11.2; 96.7% of respondents had some non-motor symptoms. The median ALSFRS-R was 32.0, and seven (21.2%) of the respondents had a PHQ-9 score of 10 or higher. Fatigue was the most common non-motor symptom (81.8%), followed by pain (60.6%), defecation disorders (57.6%), sleep disorders (48.5%), sialorrhea (48.5%), and sexual problems (24.2%). Fatigue was more frequent in females (P = 0.03). Among the non-motor symptoms, pain was the most common factor affecting QoL, followed by fatigue. More than 90% of ALS patients answered that they had never consulted a physician/counselor about sexual problems. Patients with pain had higher PHQ-9 scores than those without (P = 0.01). There was no correlation between the ALSFRS-R score and QoL and PHQ-9. [Conclusions] Most patients with amyotrophic lateral sclerosis had non-motor symptoms, and fatigue and pain were the most common. We showed that many non-motor symptoms affected QoL without correlating with ALSFRS-R score. Attention should be paid to those even if the motor symptoms of ALS are mild. |
format | Online Article Text |
id | pubmed-10505101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-105051012023-09-18 Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis Hirayama, Takehisa Shibukawa, Mari Yanagihashi, Masaru Warita, Hitoshi Atsuta, Naoki Yamanaka, Koji Kano, Osamu Acta Neurol Belg Original Article [Objective] Few studies have comprehensively investigated the non-motor symptoms of amyotrophic lateral sclerosis (ALS). We aimed to investigate this aspect of ALS. [Methods] We held a nationwide webinar, titled “ALS Café,” and distributed self-report questionnaires to ALS patients. In addition to the frequency of non-motor symptoms such as fatigue, pain, sleep disorders, defecation disorders, sialorrhea, and sexual problems, we evaluated the quality of life (QoL), ALS Functional Rating Scale-Revised (ALSFRS-R), and Patient Health Questionnaire-9 (PHQ-9). [Results] The average age of the 33 respondents (19 male, 14 female) was 60.8 ± 11.2; 96.7% of respondents had some non-motor symptoms. The median ALSFRS-R was 32.0, and seven (21.2%) of the respondents had a PHQ-9 score of 10 or higher. Fatigue was the most common non-motor symptom (81.8%), followed by pain (60.6%), defecation disorders (57.6%), sleep disorders (48.5%), sialorrhea (48.5%), and sexual problems (24.2%). Fatigue was more frequent in females (P = 0.03). Among the non-motor symptoms, pain was the most common factor affecting QoL, followed by fatigue. More than 90% of ALS patients answered that they had never consulted a physician/counselor about sexual problems. Patients with pain had higher PHQ-9 scores than those without (P = 0.01). There was no correlation between the ALSFRS-R score and QoL and PHQ-9. [Conclusions] Most patients with amyotrophic lateral sclerosis had non-motor symptoms, and fatigue and pain were the most common. We showed that many non-motor symptoms affected QoL without correlating with ALSFRS-R score. Attention should be paid to those even if the motor symptoms of ALS are mild. Springer International Publishing 2022-08-20 2023 /pmc/articles/PMC10505101/ /pubmed/35987973 http://dx.doi.org/10.1007/s13760-022-02036-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Hirayama, Takehisa Shibukawa, Mari Yanagihashi, Masaru Warita, Hitoshi Atsuta, Naoki Yamanaka, Koji Kano, Osamu Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis |
title | Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis |
title_full | Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis |
title_fullStr | Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis |
title_full_unstemmed | Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis |
title_short | Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis |
title_sort | investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505101/ https://www.ncbi.nlm.nih.gov/pubmed/35987973 http://dx.doi.org/10.1007/s13760-022-02036-6 |
work_keys_str_mv | AT hirayamatakehisa investigationofnonmotorsymptomsinpatientswithamyotrophiclateralsclerosis AT shibukawamari investigationofnonmotorsymptomsinpatientswithamyotrophiclateralsclerosis AT yanagihashimasaru investigationofnonmotorsymptomsinpatientswithamyotrophiclateralsclerosis AT waritahitoshi investigationofnonmotorsymptomsinpatientswithamyotrophiclateralsclerosis AT atsutanaoki investigationofnonmotorsymptomsinpatientswithamyotrophiclateralsclerosis AT yamanakakoji investigationofnonmotorsymptomsinpatientswithamyotrophiclateralsclerosis AT kanoosamu investigationofnonmotorsymptomsinpatientswithamyotrophiclateralsclerosis |