Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis

The β-lactamase of Mycobacterium tuberculosis, BlaC, hydrolyzes β-lactam antibiotics, hindering the use of these antibiotics for the treatment of tuberculosis. Inhibitors, such as avibactam, can reversibly inhibit the enzyme, allowing for the development of combination therapies using both antibioti...

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Detalles Bibliográficos
Autores principales: van Alen, Ilona, Aguirre García, Mayra A., Maaskant, Janneke J., Kuijl, Coenraad P., Bitter, Wilbert, Meijer, Annemarie H., Ubbink, Marcellus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505137/
https://www.ncbi.nlm.nih.gov/pubmed/37717068
http://dx.doi.org/10.1038/s41598-023-42152-8

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