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Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis

Background and hypothesis: Motor abnormalities are predictive of psychosis onset in individuals at clinical high risk (CHR) for psychosis and are tied to its progression. We hypothesize that these motor abnormalities also disrupt their speech production (a highly complex motor behavior) and predict...

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Autores principales: Hitczenko, Kasia, Segal, Yael, Keshet, Joseph, Goldrick, Matthew, Mittal, Vijay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505148/
https://www.ncbi.nlm.nih.gov/pubmed/37717025
http://dx.doi.org/10.1038/s41537-023-00382-9
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author Hitczenko, Kasia
Segal, Yael
Keshet, Joseph
Goldrick, Matthew
Mittal, Vijay A.
author_facet Hitczenko, Kasia
Segal, Yael
Keshet, Joseph
Goldrick, Matthew
Mittal, Vijay A.
author_sort Hitczenko, Kasia
collection PubMed
description Background and hypothesis: Motor abnormalities are predictive of psychosis onset in individuals at clinical high risk (CHR) for psychosis and are tied to its progression. We hypothesize that these motor abnormalities also disrupt their speech production (a highly complex motor behavior) and predict CHR individuals will produce more variable speech than healthy controls, and that this variability will relate to symptom severity, motor measures, and psychosis-risk calculator risk scores. Study design: We measure variability in speech production (variability in consonants, vowels, speech rate, and pausing/timing) in N = 58 CHR participants and N = 67 healthy controls. Three different tasks are used to elicit speech: diadochokinetic speech (rapidly-repeated syllables e.g., papapa…, pataka…), read speech, and spontaneously-generated speech. Study results: Individuals in the CHR group produced more variable consonants and exhibited greater speech rate variability than healthy controls in two of the three speech tasks (diadochokinetic and read speech). While there were no significant correlations between speech measures and remotely-obtained motor measures, symptom severity, or conversion risk scores, these comparisons may be under-powered (in part due to challenges of remote data collection during the COVID-19 pandemic). Conclusion: This study provides a thorough and theory-driven first look at how speech production is affected in this at-risk population and speaks to the promise and challenges facing this approach moving forward.
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spelling pubmed-105051482023-09-18 Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis Hitczenko, Kasia Segal, Yael Keshet, Joseph Goldrick, Matthew Mittal, Vijay A. Schizophrenia (Heidelb) Article Background and hypothesis: Motor abnormalities are predictive of psychosis onset in individuals at clinical high risk (CHR) for psychosis and are tied to its progression. We hypothesize that these motor abnormalities also disrupt their speech production (a highly complex motor behavior) and predict CHR individuals will produce more variable speech than healthy controls, and that this variability will relate to symptom severity, motor measures, and psychosis-risk calculator risk scores. Study design: We measure variability in speech production (variability in consonants, vowels, speech rate, and pausing/timing) in N = 58 CHR participants and N = 67 healthy controls. Three different tasks are used to elicit speech: diadochokinetic speech (rapidly-repeated syllables e.g., papapa…, pataka…), read speech, and spontaneously-generated speech. Study results: Individuals in the CHR group produced more variable consonants and exhibited greater speech rate variability than healthy controls in two of the three speech tasks (diadochokinetic and read speech). While there were no significant correlations between speech measures and remotely-obtained motor measures, symptom severity, or conversion risk scores, these comparisons may be under-powered (in part due to challenges of remote data collection during the COVID-19 pandemic). Conclusion: This study provides a thorough and theory-driven first look at how speech production is affected in this at-risk population and speaks to the promise and challenges facing this approach moving forward. Nature Publishing Group UK 2023-09-16 /pmc/articles/PMC10505148/ /pubmed/37717025 http://dx.doi.org/10.1038/s41537-023-00382-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hitczenko, Kasia
Segal, Yael
Keshet, Joseph
Goldrick, Matthew
Mittal, Vijay A.
Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis
title Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis
title_full Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis
title_fullStr Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis
title_full_unstemmed Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis
title_short Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis
title_sort speech characteristics yield important clues about motor function: speech variability in individuals at clinical high-risk for psychosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505148/
https://www.ncbi.nlm.nih.gov/pubmed/37717025
http://dx.doi.org/10.1038/s41537-023-00382-9
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