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Near-field projection optical microscope (NPOM) as a new approach to nanoscale super-resolved imaging

A new super-resolution method, entitled Near-field Projection Optical Microscopy (NPOM), is presented. This novel technique enables the imaging of nanoscale objects without the need for surface scanning, as is usually required in existing methods such as NSOM (near-field scanning optical microscope)...

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Autores principales: Sanjeev, Abhijit, Glukhov, David, Salahudeen Rafeeka, Rinsa, Karsenty, Avi, Zalevsky, Zeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505152/
https://www.ncbi.nlm.nih.gov/pubmed/37717077
http://dx.doi.org/10.1038/s41598-023-41978-6
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author Sanjeev, Abhijit
Glukhov, David
Salahudeen Rafeeka, Rinsa
Karsenty, Avi
Zalevsky, Zeev
author_facet Sanjeev, Abhijit
Glukhov, David
Salahudeen Rafeeka, Rinsa
Karsenty, Avi
Zalevsky, Zeev
author_sort Sanjeev, Abhijit
collection PubMed
description A new super-resolution method, entitled Near-field Projection Optical Microscopy (NPOM), is presented. This novel technique enables the imaging of nanoscale objects without the need for surface scanning, as is usually required in existing methods such as NSOM (near-field scanning optical microscope). The main advantage of the proposed concept, besides the elimination of the need for a mechanical scanning mechanism, is that the full field of regard/view is imaged simultaneously and not point-by-point as in scanning-based techniques. Furthermore, by using compressed sensing, the number of projected patterns needed to decompose the spatial information of the inspected object can be made smaller than the obtainable points of spatial resolution. In addition to the development of mathematical formalism, this paper presents the results of a series of complementary numerical tests, using various objects and patterns, that were performed to verify the accuracy of the reconstruction capabilities. We have also performed a proof of concept experiment to support the numerical formalism.
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spelling pubmed-105051522023-09-18 Near-field projection optical microscope (NPOM) as a new approach to nanoscale super-resolved imaging Sanjeev, Abhijit Glukhov, David Salahudeen Rafeeka, Rinsa Karsenty, Avi Zalevsky, Zeev Sci Rep Article A new super-resolution method, entitled Near-field Projection Optical Microscopy (NPOM), is presented. This novel technique enables the imaging of nanoscale objects without the need for surface scanning, as is usually required in existing methods such as NSOM (near-field scanning optical microscope). The main advantage of the proposed concept, besides the elimination of the need for a mechanical scanning mechanism, is that the full field of regard/view is imaged simultaneously and not point-by-point as in scanning-based techniques. Furthermore, by using compressed sensing, the number of projected patterns needed to decompose the spatial information of the inspected object can be made smaller than the obtainable points of spatial resolution. In addition to the development of mathematical formalism, this paper presents the results of a series of complementary numerical tests, using various objects and patterns, that were performed to verify the accuracy of the reconstruction capabilities. We have also performed a proof of concept experiment to support the numerical formalism. Nature Publishing Group UK 2023-09-16 /pmc/articles/PMC10505152/ /pubmed/37717077 http://dx.doi.org/10.1038/s41598-023-41978-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sanjeev, Abhijit
Glukhov, David
Salahudeen Rafeeka, Rinsa
Karsenty, Avi
Zalevsky, Zeev
Near-field projection optical microscope (NPOM) as a new approach to nanoscale super-resolved imaging
title Near-field projection optical microscope (NPOM) as a new approach to nanoscale super-resolved imaging
title_full Near-field projection optical microscope (NPOM) as a new approach to nanoscale super-resolved imaging
title_fullStr Near-field projection optical microscope (NPOM) as a new approach to nanoscale super-resolved imaging
title_full_unstemmed Near-field projection optical microscope (NPOM) as a new approach to nanoscale super-resolved imaging
title_short Near-field projection optical microscope (NPOM) as a new approach to nanoscale super-resolved imaging
title_sort near-field projection optical microscope (npom) as a new approach to nanoscale super-resolved imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505152/
https://www.ncbi.nlm.nih.gov/pubmed/37717077
http://dx.doi.org/10.1038/s41598-023-41978-6
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