Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA

The expanded hexanucleotide GGGGCC repeat mutation in the C9orf72 gene is the main genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Under one disease mechanism, sense and antisense transcripts of the repeat are predicted to bind various RNA-binding proteins, compromise the...

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Detalles Bibliográficos
Autores principales: Malnar Črnigoj, Mirjana, Čerček, Urša, Yin, Xiaoke, Ho, Manh Tin, Repic Lampret, Barbka, Neumann, Manuela, Hermann, Andreas, Rouleau, Guy, Suter, Beat, Mayr, Manuel, Rogelj, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505166/
https://www.ncbi.nlm.nih.gov/pubmed/37717009
http://dx.doi.org/10.1038/s41467-023-41511-3

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