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Taxol acts differently on different tubulin isotypes

Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice. We show here that taxol has different effects on different single-isotype microtubule lattices. Using in vitro reconstitution, we demonstrate that single-isotype α1β4 GDP-tubulin lattices are stabilise...

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Detalles Bibliográficos
Autores principales:	Chew, Yean Ming, Cross, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505170/ https://www.ncbi.nlm.nih.gov/pubmed/37717119 http://dx.doi.org/10.1038/s42003-023-05306-y

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