Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy. Here we show that short peptides that promiscuously bind both chemokine cl...

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Detalles Bibliográficos
Autores principales: Vales, Serena, Kryukova, Jhanna, Chandra, Soumyanetra, Smagurauskaite, Gintare, Payne, Megan, Clark, Charlie J., Hafner, Katrin, Mburu, Philomena, Denisov, Stepan, Davies, Graham, Outeiral, Carlos, Deane, Charlotte M., Morris, Garrett M., Bhattacharya, Shoumo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505172/
https://www.ncbi.nlm.nih.gov/pubmed/37717048
http://dx.doi.org/10.1038/s41467-023-41488-z

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