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Pharmacotherapy in patients with vasomotor disorders
BACKGROUND: Anginal symptoms in patients with non-obstructive coronary artery disease are frequently related to vasomotor disorders of the coronary circulation. Although frequently overlooked, a distinct diagnosis of different vasomotor disorders can be made by intracoronary function testing. Early...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505589/ https://www.ncbi.nlm.nih.gov/pubmed/37727753 http://dx.doi.org/10.1016/j.ijcha.2023.101267 |
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author | Boerhout, C.K.M. Feenstra, R.G.T. van de Hoef, T.P. Piek, J.J. Beijk, M.A.M. |
author_facet | Boerhout, C.K.M. Feenstra, R.G.T. van de Hoef, T.P. Piek, J.J. Beijk, M.A.M. |
author_sort | Boerhout, C.K.M. |
collection | PubMed |
description | BACKGROUND: Anginal symptoms in patients with non-obstructive coronary artery disease are frequently related to vasomotor disorders of the coronary circulation. Although frequently overlooked, a distinct diagnosis of different vasomotor disorders can be made by intracoronary function testing. Early detection and treatment seems beneficial, but little evidence is available for the medical treatment of these disorders. Nevertheless, there are several pharmacotherapeutic options available to treat these patients and improve quality of life. METHODS & FINDINGS: We performed an extensive yet non-systematic literature search to explore available pharmacotherapeutic strategies for addressing vasomotor disorders in individuals experiencing angina and non-obstructive coronary artery disease. This article presents a comprehensive overview of therapeutic possibilities for patients exhibiting abnormal vasoconstriction (such as spasm) and abnormal vasodilation (like coronary microvascular dysfunction). CONCLUSION: Treatment of vasomotor disorders can be very challenging, but a general treatment algorithm based on the existing evidence and the best available current practice is feasible. |
format | Online Article Text |
id | pubmed-10505589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105055892023-09-19 Pharmacotherapy in patients with vasomotor disorders Boerhout, C.K.M. Feenstra, R.G.T. van de Hoef, T.P. Piek, J.J. Beijk, M.A.M. Int J Cardiol Heart Vasc Review BACKGROUND: Anginal symptoms in patients with non-obstructive coronary artery disease are frequently related to vasomotor disorders of the coronary circulation. Although frequently overlooked, a distinct diagnosis of different vasomotor disorders can be made by intracoronary function testing. Early detection and treatment seems beneficial, but little evidence is available for the medical treatment of these disorders. Nevertheless, there are several pharmacotherapeutic options available to treat these patients and improve quality of life. METHODS & FINDINGS: We performed an extensive yet non-systematic literature search to explore available pharmacotherapeutic strategies for addressing vasomotor disorders in individuals experiencing angina and non-obstructive coronary artery disease. This article presents a comprehensive overview of therapeutic possibilities for patients exhibiting abnormal vasoconstriction (such as spasm) and abnormal vasodilation (like coronary microvascular dysfunction). CONCLUSION: Treatment of vasomotor disorders can be very challenging, but a general treatment algorithm based on the existing evidence and the best available current practice is feasible. Elsevier 2023-09-08 /pmc/articles/PMC10505589/ /pubmed/37727753 http://dx.doi.org/10.1016/j.ijcha.2023.101267 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boerhout, C.K.M. Feenstra, R.G.T. van de Hoef, T.P. Piek, J.J. Beijk, M.A.M. Pharmacotherapy in patients with vasomotor disorders |
title | Pharmacotherapy in patients with vasomotor disorders |
title_full | Pharmacotherapy in patients with vasomotor disorders |
title_fullStr | Pharmacotherapy in patients with vasomotor disorders |
title_full_unstemmed | Pharmacotherapy in patients with vasomotor disorders |
title_short | Pharmacotherapy in patients with vasomotor disorders |
title_sort | pharmacotherapy in patients with vasomotor disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505589/ https://www.ncbi.nlm.nih.gov/pubmed/37727753 http://dx.doi.org/10.1016/j.ijcha.2023.101267 |
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