IL-32 as a potential biomarker and therapeutic target in skin inflammation

IL-32 is a recently described cytokine that performs a variety of functions under inflammatory conditions. Serum IL-32 has been shown to be elevated in several diseases, including type 2 diabetes, cancer, systemic lupus erythematosus, HIV infection, and atopic diseases including atopic dermatitis. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Wallimann, Alexandra, Schenk, Mirjam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505650/
https://www.ncbi.nlm.nih.gov/pubmed/37727785
http://dx.doi.org/10.3389/fimmu.2023.1264236
_version_ 1785106947411804160
author Wallimann, Alexandra
Schenk, Mirjam
author_facet Wallimann, Alexandra
Schenk, Mirjam
author_sort Wallimann, Alexandra
collection PubMed
description IL-32 is a recently described cytokine that performs a variety of functions under inflammatory conditions. Serum IL-32 has been shown to be elevated in several diseases, including type 2 diabetes, cancer, systemic lupus erythematosus, HIV infection, and atopic diseases including atopic dermatitis. There are nine different isoforms of IL-32, with IL-32γ being the most biologically active one. The following review summarizes the different roles of the various IL-32 isoforms in the context of skin inflammation, with a focus on atopic dermatitis.
format Online
Article
Text
id pubmed-10505650
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-105056502023-09-19 IL-32 as a potential biomarker and therapeutic target in skin inflammation Wallimann, Alexandra Schenk, Mirjam Front Immunol Immunology IL-32 is a recently described cytokine that performs a variety of functions under inflammatory conditions. Serum IL-32 has been shown to be elevated in several diseases, including type 2 diabetes, cancer, systemic lupus erythematosus, HIV infection, and atopic diseases including atopic dermatitis. There are nine different isoforms of IL-32, with IL-32γ being the most biologically active one. The following review summarizes the different roles of the various IL-32 isoforms in the context of skin inflammation, with a focus on atopic dermatitis. Frontiers Media S.A. 2023-09-01 /pmc/articles/PMC10505650/ /pubmed/37727785 http://dx.doi.org/10.3389/fimmu.2023.1264236 Text en Copyright © 2023 Wallimann and Schenk https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wallimann, Alexandra
Schenk, Mirjam
IL-32 as a potential biomarker and therapeutic target in skin inflammation
title IL-32 as a potential biomarker and therapeutic target in skin inflammation
title_full IL-32 as a potential biomarker and therapeutic target in skin inflammation
title_fullStr IL-32 as a potential biomarker and therapeutic target in skin inflammation
title_full_unstemmed IL-32 as a potential biomarker and therapeutic target in skin inflammation
title_short IL-32 as a potential biomarker and therapeutic target in skin inflammation
title_sort il-32 as a potential biomarker and therapeutic target in skin inflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505650/
https://www.ncbi.nlm.nih.gov/pubmed/37727785
http://dx.doi.org/10.3389/fimmu.2023.1264236
work_keys_str_mv AT wallimannalexandra il32asapotentialbiomarkerandtherapeutictargetinskininflammation
AT schenkmirjam il32asapotentialbiomarkerandtherapeutictargetinskininflammation

Ejemplares similares