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Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia
BACKGROUND: little is known regarding the prognostic value of soluble CD200 (sCD200)in chronic lymphocytic leukemia patients. Therefore, the objective of our study is to address the prognostic value of sCD200 antigen concentration on CLL patients outcome. METHODS: Determination of serum sCD200 was d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505868/ https://www.ncbi.nlm.nih.gov/pubmed/37378922 http://dx.doi.org/10.31557/APJCP.2023.24.6.1943 |
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author | Aref, Salah El Tantawy, Ahmed Gouda, Enas Ayed, Mohamed |
author_facet | Aref, Salah El Tantawy, Ahmed Gouda, Enas Ayed, Mohamed |
author_sort | Aref, Salah |
collection | PubMed |
description | BACKGROUND: little is known regarding the prognostic value of soluble CD200 (sCD200)in chronic lymphocytic leukemia patients. Therefore, the objective of our study is to address the prognostic value of sCD200 antigen concentration on CLL patients outcome. METHODS: Determination of serum sCD200 was done using ELISA kit in 158 CLL patients at diagnosis before start of therapy beside 21 healthy controls. RESULTS: sCD200 concentration levels was significantly higher in CLL patients as compared to healthy controls. High sCD200 was associated with poor prognostic markers (high expression of CD38+% and ZAP70+, high LDH, high risk Rai stages, unfavorable cytogenetic finding, time to first treatment (TTT) as well as patients outcome (P<0.001 for All). sCD200 at cut-off value ( 752.5 pg/ml) could predicts TTT with specificity 83.4%. CONCLUSION: Determination of sCD200 concentration levels at diagnosis could be used as a prognostic biomarker in CLL patients. |
format | Online Article Text |
id | pubmed-10505868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-105058682023-09-19 Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia Aref, Salah El Tantawy, Ahmed Gouda, Enas Ayed, Mohamed Asian Pac J Cancer Prev Research Article BACKGROUND: little is known regarding the prognostic value of soluble CD200 (sCD200)in chronic lymphocytic leukemia patients. Therefore, the objective of our study is to address the prognostic value of sCD200 antigen concentration on CLL patients outcome. METHODS: Determination of serum sCD200 was done using ELISA kit in 158 CLL patients at diagnosis before start of therapy beside 21 healthy controls. RESULTS: sCD200 concentration levels was significantly higher in CLL patients as compared to healthy controls. High sCD200 was associated with poor prognostic markers (high expression of CD38+% and ZAP70+, high LDH, high risk Rai stages, unfavorable cytogenetic finding, time to first treatment (TTT) as well as patients outcome (P<0.001 for All). sCD200 at cut-off value ( 752.5 pg/ml) could predicts TTT with specificity 83.4%. CONCLUSION: Determination of sCD200 concentration levels at diagnosis could be used as a prognostic biomarker in CLL patients. West Asia Organization for Cancer Prevention 2023 /pmc/articles/PMC10505868/ /pubmed/37378922 http://dx.doi.org/10.31557/APJCP.2023.24.6.1943 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Research Article Aref, Salah El Tantawy, Ahmed Gouda, Enas Ayed, Mohamed Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia |
title | Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia |
title_full | Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia |
title_fullStr | Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia |
title_full_unstemmed | Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia |
title_short | Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia |
title_sort | prognostic value of serum cd200 concentrations in chronic lymphocytic leukemia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505868/ https://www.ncbi.nlm.nih.gov/pubmed/37378922 http://dx.doi.org/10.31557/APJCP.2023.24.6.1943 |
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