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Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia

BACKGROUND: little is known regarding the prognostic value of soluble CD200 (sCD200)in chronic lymphocytic leukemia patients. Therefore, the objective of our study is to address the prognostic value of sCD200 antigen concentration on CLL patients outcome. METHODS: Determination of serum sCD200 was d...

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Autores principales: Aref, Salah, El Tantawy, Ahmed, Gouda, Enas, Ayed, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505868/
https://www.ncbi.nlm.nih.gov/pubmed/37378922
http://dx.doi.org/10.31557/APJCP.2023.24.6.1943
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author Aref, Salah
El Tantawy, Ahmed
Gouda, Enas
Ayed, Mohamed
author_facet Aref, Salah
El Tantawy, Ahmed
Gouda, Enas
Ayed, Mohamed
author_sort Aref, Salah
collection PubMed
description BACKGROUND: little is known regarding the prognostic value of soluble CD200 (sCD200)in chronic lymphocytic leukemia patients. Therefore, the objective of our study is to address the prognostic value of sCD200 antigen concentration on CLL patients outcome. METHODS: Determination of serum sCD200 was done using ELISA kit in 158 CLL patients at diagnosis before start of therapy beside 21 healthy controls. RESULTS: sCD200 concentration levels was significantly higher in CLL patients as compared to healthy controls. High sCD200 was associated with poor prognostic markers (high expression of CD38+% and ZAP70+, high LDH, high risk Rai stages, unfavorable cytogenetic finding, time to first treatment (TTT) as well as patients outcome (P<0.001 for All). sCD200 at cut-off value ( 752.5 pg/ml) could predicts TTT with specificity 83.4%. CONCLUSION: Determination of sCD200 concentration levels at diagnosis could be used as a prognostic biomarker in CLL patients.
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spelling pubmed-105058682023-09-19 Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia Aref, Salah El Tantawy, Ahmed Gouda, Enas Ayed, Mohamed Asian Pac J Cancer Prev Research Article BACKGROUND: little is known regarding the prognostic value of soluble CD200 (sCD200)in chronic lymphocytic leukemia patients. Therefore, the objective of our study is to address the prognostic value of sCD200 antigen concentration on CLL patients outcome. METHODS: Determination of serum sCD200 was done using ELISA kit in 158 CLL patients at diagnosis before start of therapy beside 21 healthy controls. RESULTS: sCD200 concentration levels was significantly higher in CLL patients as compared to healthy controls. High sCD200 was associated with poor prognostic markers (high expression of CD38+% and ZAP70+, high LDH, high risk Rai stages, unfavorable cytogenetic finding, time to first treatment (TTT) as well as patients outcome (P<0.001 for All). sCD200 at cut-off value ( 752.5 pg/ml) could predicts TTT with specificity 83.4%. CONCLUSION: Determination of sCD200 concentration levels at diagnosis could be used as a prognostic biomarker in CLL patients. West Asia Organization for Cancer Prevention 2023 /pmc/articles/PMC10505868/ /pubmed/37378922 http://dx.doi.org/10.31557/APJCP.2023.24.6.1943 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research Article
Aref, Salah
El Tantawy, Ahmed
Gouda, Enas
Ayed, Mohamed
Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia
title Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia
title_full Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia
title_fullStr Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia
title_full_unstemmed Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia
title_short Prognostic Value of Serum CD200 Concentrations in Chronic Lymphocytic Leukemia
title_sort prognostic value of serum cd200 concentrations in chronic lymphocytic leukemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505868/
https://www.ncbi.nlm.nih.gov/pubmed/37378922
http://dx.doi.org/10.31557/APJCP.2023.24.6.1943
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