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The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients

BACKGROUND: MiR27a plays an important role in carcinogenesis, cell proliferation, apoptosis, invasion, migration and angiogenesis. Several studies have identified an important role of pre-miR27a (rs895819) A>G polymorphism in several types of cancer. This research aims to investigate the associat...

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Autores principales: Sanguansin, Sirima, Saelee, Pensri, Kritsirivuttinan, Kanyanan, Pongstaporn, Wanida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505893/
https://www.ncbi.nlm.nih.gov/pubmed/37378936
http://dx.doi.org/10.31557/APJCP.2023.24.6.2055
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author Sanguansin, Sirima
Saelee, Pensri
Kritsirivuttinan, Kanyanan
Pongstaporn, Wanida
author_facet Sanguansin, Sirima
Saelee, Pensri
Kritsirivuttinan, Kanyanan
Pongstaporn, Wanida
author_sort Sanguansin, Sirima
collection PubMed
description BACKGROUND: MiR27a plays an important role in carcinogenesis, cell proliferation, apoptosis, invasion, migration and angiogenesis. Several studies have identified an important role of pre-miR27a (rs895819) A>G polymorphism in several types of cancer. This research aims to investigate the association of pre-miR27a (rs895819) A>G and breast cancer susceptibility, clinicopathological data and survival. Blood DNA samples of 143 Thai breast cancer patients and 100 healthy Thai women were studied for pre-miR27a (rs895819) A>G polymorphism using polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP). RESULTS: The results revealed that the frequency of pre-miR27a (rs895819) A>G genotypes was not statistically significant different between breast cancer patient and normal control subjects. The rs895819 A>G genotype was significantly associated with clinicopathological parameter of grade III differentiation (P = 0.006), progesterone receptor (P = 0.011) and triple negative (P = 0.031) in breast cancer patients, but not with breast cancer susceptibility. CONCLUSION: The pre-miR27a (rs895819) A>G genotype was significantly associated with poorly differentiated, progesterone receptor and triple-negative in breast cancer patients. Therefore, pre-miR27a (rs895819) A>G may be used as a biomarker for poor prognosis.
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spelling pubmed-105058932023-09-19 The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients Sanguansin, Sirima Saelee, Pensri Kritsirivuttinan, Kanyanan Pongstaporn, Wanida Asian Pac J Cancer Prev Research Article BACKGROUND: MiR27a plays an important role in carcinogenesis, cell proliferation, apoptosis, invasion, migration and angiogenesis. Several studies have identified an important role of pre-miR27a (rs895819) A>G polymorphism in several types of cancer. This research aims to investigate the association of pre-miR27a (rs895819) A>G and breast cancer susceptibility, clinicopathological data and survival. Blood DNA samples of 143 Thai breast cancer patients and 100 healthy Thai women were studied for pre-miR27a (rs895819) A>G polymorphism using polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP). RESULTS: The results revealed that the frequency of pre-miR27a (rs895819) A>G genotypes was not statistically significant different between breast cancer patient and normal control subjects. The rs895819 A>G genotype was significantly associated with clinicopathological parameter of grade III differentiation (P = 0.006), progesterone receptor (P = 0.011) and triple negative (P = 0.031) in breast cancer patients, but not with breast cancer susceptibility. CONCLUSION: The pre-miR27a (rs895819) A>G genotype was significantly associated with poorly differentiated, progesterone receptor and triple-negative in breast cancer patients. Therefore, pre-miR27a (rs895819) A>G may be used as a biomarker for poor prognosis. West Asia Organization for Cancer Prevention 2023 /pmc/articles/PMC10505893/ /pubmed/37378936 http://dx.doi.org/10.31557/APJCP.2023.24.6.2055 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research Article
Sanguansin, Sirima
Saelee, Pensri
Kritsirivuttinan, Kanyanan
Pongstaporn, Wanida
The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients
title The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients
title_full The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients
title_fullStr The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients
title_full_unstemmed The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients
title_short The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients
title_sort association of pre-mir27a gene polymorphism and clinicopathological data in thai breast cancer patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505893/
https://www.ncbi.nlm.nih.gov/pubmed/37378936
http://dx.doi.org/10.31557/APJCP.2023.24.6.2055
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