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NME6: ribonucleotide salvage sustains mitochondrial transcription
The building blocks for RNA and DNA are made in the cytosol, meaning mitochondria depend on the import and salvage of ribonucleoside triphosphates (rNTPs) and deoxyribonucleoside triphosphates (dNTPs) for the synthesis of their own genetic material. While extensive research has focused on mitochondr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505902/ https://www.ncbi.nlm.nih.gov/pubmed/37548337 http://dx.doi.org/10.15252/embj.2023114990 |
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author | Wanrooij, Paulina H Chabes, Andrei |
author_facet | Wanrooij, Paulina H Chabes, Andrei |
author_sort | Wanrooij, Paulina H |
collection | PubMed |
description | The building blocks for RNA and DNA are made in the cytosol, meaning mitochondria depend on the import and salvage of ribonucleoside triphosphates (rNTPs) and deoxyribonucleoside triphosphates (dNTPs) for the synthesis of their own genetic material. While extensive research has focused on mitochondrial dNTP homeostasis due to its defects being associated with various mitochondrial DNA (mtDNA) depletion and deletion syndromes, the investigation of mitochondrial rNTP homeostasis has received relatively little attention. In this issue of the EMBO Journal, Grotehans et al provide compelling evidence of a major role for NME6, a mitochondrial nucleoside diphosphate kinase, in the conversion of pyrimidine ribonucleoside diphosphates into the corresponding triphosphates. These data also suggest a significant physiological role for NME6, as its absence results in the depletion of mitochondrial transcripts and destabilization of the electron transport chain (Grotehans et al, 2023). |
format | Online Article Text |
id | pubmed-10505902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105059022023-09-19 NME6: ribonucleotide salvage sustains mitochondrial transcription Wanrooij, Paulina H Chabes, Andrei EMBO J News & Views The building blocks for RNA and DNA are made in the cytosol, meaning mitochondria depend on the import and salvage of ribonucleoside triphosphates (rNTPs) and deoxyribonucleoside triphosphates (dNTPs) for the synthesis of their own genetic material. While extensive research has focused on mitochondrial dNTP homeostasis due to its defects being associated with various mitochondrial DNA (mtDNA) depletion and deletion syndromes, the investigation of mitochondrial rNTP homeostasis has received relatively little attention. In this issue of the EMBO Journal, Grotehans et al provide compelling evidence of a major role for NME6, a mitochondrial nucleoside diphosphate kinase, in the conversion of pyrimidine ribonucleoside diphosphates into the corresponding triphosphates. These data also suggest a significant physiological role for NME6, as its absence results in the depletion of mitochondrial transcripts and destabilization of the electron transport chain (Grotehans et al, 2023). John Wiley and Sons Inc. 2023-08-07 /pmc/articles/PMC10505902/ /pubmed/37548337 http://dx.doi.org/10.15252/embj.2023114990 Text en © 2023 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | News & Views Wanrooij, Paulina H Chabes, Andrei NME6: ribonucleotide salvage sustains mitochondrial transcription |
title | NME6: ribonucleotide salvage sustains mitochondrial transcription |
title_full | NME6: ribonucleotide salvage sustains mitochondrial transcription |
title_fullStr | NME6: ribonucleotide salvage sustains mitochondrial transcription |
title_full_unstemmed | NME6: ribonucleotide salvage sustains mitochondrial transcription |
title_short | NME6: ribonucleotide salvage sustains mitochondrial transcription |
title_sort | nme6: ribonucleotide salvage sustains mitochondrial transcription |
topic | News & Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505902/ https://www.ncbi.nlm.nih.gov/pubmed/37548337 http://dx.doi.org/10.15252/embj.2023114990 |
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