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NME6: ribonucleotide salvage sustains mitochondrial transcription

The building blocks for RNA and DNA are made in the cytosol, meaning mitochondria depend on the import and salvage of ribonucleoside triphosphates (rNTPs) and deoxyribonucleoside triphosphates (dNTPs) for the synthesis of their own genetic material. While extensive research has focused on mitochondr...

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Detalles Bibliográficos
Autores principales: Wanrooij, Paulina H, Chabes, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505902/
https://www.ncbi.nlm.nih.gov/pubmed/37548337
http://dx.doi.org/10.15252/embj.2023114990
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author Wanrooij, Paulina H
Chabes, Andrei
author_facet Wanrooij, Paulina H
Chabes, Andrei
author_sort Wanrooij, Paulina H
collection PubMed
description The building blocks for RNA and DNA are made in the cytosol, meaning mitochondria depend on the import and salvage of ribonucleoside triphosphates (rNTPs) and deoxyribonucleoside triphosphates (dNTPs) for the synthesis of their own genetic material. While extensive research has focused on mitochondrial dNTP homeostasis due to its defects being associated with various mitochondrial DNA (mtDNA) depletion and deletion syndromes, the investigation of mitochondrial rNTP homeostasis has received relatively little attention. In this issue of the EMBO Journal, Grotehans et al provide compelling evidence of a major role for NME6, a mitochondrial nucleoside diphosphate kinase, in the conversion of pyrimidine ribonucleoside diphosphates into the corresponding triphosphates. These data also suggest a significant physiological role for NME6, as its absence results in the depletion of mitochondrial transcripts and destabilization of the electron transport chain (Grotehans et al, 2023).
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spelling pubmed-105059022023-09-19 NME6: ribonucleotide salvage sustains mitochondrial transcription Wanrooij, Paulina H Chabes, Andrei EMBO J News & Views The building blocks for RNA and DNA are made in the cytosol, meaning mitochondria depend on the import and salvage of ribonucleoside triphosphates (rNTPs) and deoxyribonucleoside triphosphates (dNTPs) for the synthesis of their own genetic material. While extensive research has focused on mitochondrial dNTP homeostasis due to its defects being associated with various mitochondrial DNA (mtDNA) depletion and deletion syndromes, the investigation of mitochondrial rNTP homeostasis has received relatively little attention. In this issue of the EMBO Journal, Grotehans et al provide compelling evidence of a major role for NME6, a mitochondrial nucleoside diphosphate kinase, in the conversion of pyrimidine ribonucleoside diphosphates into the corresponding triphosphates. These data also suggest a significant physiological role for NME6, as its absence results in the depletion of mitochondrial transcripts and destabilization of the electron transport chain (Grotehans et al, 2023). John Wiley and Sons Inc. 2023-08-07 /pmc/articles/PMC10505902/ /pubmed/37548337 http://dx.doi.org/10.15252/embj.2023114990 Text en © 2023 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Wanrooij, Paulina H
Chabes, Andrei
NME6: ribonucleotide salvage sustains mitochondrial transcription
title NME6: ribonucleotide salvage sustains mitochondrial transcription
title_full NME6: ribonucleotide salvage sustains mitochondrial transcription
title_fullStr NME6: ribonucleotide salvage sustains mitochondrial transcription
title_full_unstemmed NME6: ribonucleotide salvage sustains mitochondrial transcription
title_short NME6: ribonucleotide salvage sustains mitochondrial transcription
title_sort nme6: ribonucleotide salvage sustains mitochondrial transcription
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505902/
https://www.ncbi.nlm.nih.gov/pubmed/37548337
http://dx.doi.org/10.15252/embj.2023114990
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