Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity

DNA single‐strand breaks (SSBs) disrupt DNA replication and induce chromosome breakage. However, whether SSBs induce chromosome breakage when present behind replication forks or ahead of replication forks is unclear. To address this question, we exploited an exquisite sensitivity of SSB repair‐defec...

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Detalles Bibliográficos
Autores principales: Serrano‐Benitez, Almudena, Wells, Sophie E, Drummond‐Clarke, Lylah, Russo, Lilian C, Thomas, John Christopher, Leal, Giovanna A, Farrow, Mark, Edgerton, James Michael, Balasubramanian, Shankar, Yang, Ming, Frezza, Christian, Gautam, Amit, Brazina, Jan, Burdova, Kamila, Hoch, Nicolas C, Jackson, Stephen P, Caldecott, Keith W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505916/
https://www.ncbi.nlm.nih.gov/pubmed/37492888
http://dx.doi.org/10.15252/embj.2022113190

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