PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer

Dysregulation of the PI3K/AKT pathway is a common occurrence in high‐grade serous ovarian carcinoma (HGSOC), with the loss of the tumour suppressor PTEN in HGSOC being associated with poor prognosis. The cellular mechanisms of how PTEN loss contributes to HGSOC are largely unknown. We here utilise t...

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Detalles Bibliográficos
Autores principales: Nikolatou, Konstantina, Sandilands, Emma, Román‐Fernández, Alvaro, Cumming, Erin M, Freckmann, Eva, Lilla, Sergio, Buetow, Lori, McGarry, Lynn, Neilson, Matthew, Shaw, Robin, Strachan, David, Miller, Crispin, Huang, Danny T, McNeish, Iain A, Norman, James C, Zanivan, Sara, Bryant, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505920/
https://www.ncbi.nlm.nih.gov/pubmed/37577760
http://dx.doi.org/10.15252/embj.2023113987

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