Cargando…

Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive and neurodegenerative illness which results in alterations in cognitive development. It is characterized by loss/dysfunction of cholinergic neurons, and formation of amyloid plaques, and formation of neurofibrillary tangles, among other changes, due to hyper...

Descripción completa

Detalles Bibliográficos
Autores principales: Torres-Sánchez, Erandis D, Ortiz, Genaro G, Reyes-Uribe, Emmanuel, Torres-Jasso, Juan H, Salazar-Flores, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506003/
https://www.ncbi.nlm.nih.gov/pubmed/37727721
http://dx.doi.org/10.12998/wjcc.v11.i24.5628
_version_ 1785107028150059008
author Torres-Sánchez, Erandis D
Ortiz, Genaro G
Reyes-Uribe, Emmanuel
Torres-Jasso, Juan H
Salazar-Flores, Joel
author_facet Torres-Sánchez, Erandis D
Ortiz, Genaro G
Reyes-Uribe, Emmanuel
Torres-Jasso, Juan H
Salazar-Flores, Joel
author_sort Torres-Sánchez, Erandis D
collection PubMed
description Alzheimer’s disease (AD) is a progressive and neurodegenerative illness which results in alterations in cognitive development. It is characterized by loss/dysfunction of cholinergic neurons, and formation of amyloid plaques, and formation of neurofibrillary tangles, among other changes, due to hyperphosphorylation of tau-protein. Exposure to pesticides in humans occurs frequently due to contact with contaminated food, water, or particles. Organochlorines, organophosphates, carbamates, pyrethroids and neonicotinoids are associated with the most diagnosed incidents of severe cognitive impairment. The aim of this study was to determine the effects of these pesticides on the phosphorylation of tau protein, and its cognitive implications in the development of AD. It was found that exposure to pesticides increased the phosphorylation of tau protein at sites Ser198, Ser199, Ser202, Thr205, Ser396 and Ser404. Contact with these chemicals altered the enzymatic activities of cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta, and protein phosphatase-2A. Moreover, it altered the expression of the microtubule associated protein tau gene, and changed levels of intracellular calcium. These changes affected tau protein phosphorylation and neuroinflammation, and also increased oxidative stress. In addition, the exposed subjects had poor level of performance in tests that involved evaluation of novelty, as test on verbal, non-verbal, spatial memory, attention, and problem-solving skills.
format Online
Article
Text
id pubmed-10506003
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-105060032023-09-19 Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease Torres-Sánchez, Erandis D Ortiz, Genaro G Reyes-Uribe, Emmanuel Torres-Jasso, Juan H Salazar-Flores, Joel World J Clin Cases Minireviews Alzheimer’s disease (AD) is a progressive and neurodegenerative illness which results in alterations in cognitive development. It is characterized by loss/dysfunction of cholinergic neurons, and formation of amyloid plaques, and formation of neurofibrillary tangles, among other changes, due to hyperphosphorylation of tau-protein. Exposure to pesticides in humans occurs frequently due to contact with contaminated food, water, or particles. Organochlorines, organophosphates, carbamates, pyrethroids and neonicotinoids are associated with the most diagnosed incidents of severe cognitive impairment. The aim of this study was to determine the effects of these pesticides on the phosphorylation of tau protein, and its cognitive implications in the development of AD. It was found that exposure to pesticides increased the phosphorylation of tau protein at sites Ser198, Ser199, Ser202, Thr205, Ser396 and Ser404. Contact with these chemicals altered the enzymatic activities of cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta, and protein phosphatase-2A. Moreover, it altered the expression of the microtubule associated protein tau gene, and changed levels of intracellular calcium. These changes affected tau protein phosphorylation and neuroinflammation, and also increased oxidative stress. In addition, the exposed subjects had poor level of performance in tests that involved evaluation of novelty, as test on verbal, non-verbal, spatial memory, attention, and problem-solving skills. Baishideng Publishing Group Inc 2023-08-26 2023-08-26 /pmc/articles/PMC10506003/ /pubmed/37727721 http://dx.doi.org/10.12998/wjcc.v11.i24.5628 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Torres-Sánchez, Erandis D
Ortiz, Genaro G
Reyes-Uribe, Emmanuel
Torres-Jasso, Juan H
Salazar-Flores, Joel
Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease
title Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease
title_full Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease
title_fullStr Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease
title_full_unstemmed Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease
title_short Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease
title_sort effect of pesticides on phosphorylation of tau protein, and its influence on alzheimer’s disease
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506003/
https://www.ncbi.nlm.nih.gov/pubmed/37727721
http://dx.doi.org/10.12998/wjcc.v11.i24.5628
work_keys_str_mv AT torressanchezerandisd effectofpesticidesonphosphorylationoftauproteinanditsinfluenceonalzheimersdisease
AT ortizgenarog effectofpesticidesonphosphorylationoftauproteinanditsinfluenceonalzheimersdisease
AT reyesuribeemmanuel effectofpesticidesonphosphorylationoftauproteinanditsinfluenceonalzheimersdisease
AT torresjassojuanh effectofpesticidesonphosphorylationoftauproteinanditsinfluenceonalzheimersdisease
AT salazarfloresjoel effectofpesticidesonphosphorylationoftauproteinanditsinfluenceonalzheimersdisease