Hemin and iron increase synthesis and trigger export of xanthine oxidoreductase from hepatocytes to the circulation

We recently reported a previously unknown salutary role for xanthine oxidoreductase (XOR) in intravascular heme overload whereby hepatocellular export of XOR to the circulation was identified as a seminal step in affording protection. However, the cellular signaling and export mechanisms underpinnin...

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Detalles Bibliográficos
Autores principales: DeVallance, Evan R., Schmidt, Heidi M., Seman, Madison, Lewis, Sara E., Wood, Katherine C., Vickers, Schuyler D., Hahn, Scott A., Velayutham, Murugesan, Hileman, Emily A., Vitturi, Dario A., Leonardi, Roberta, Straub, Adam C., Kelley, Eric E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506059/
https://www.ncbi.nlm.nih.gov/pubmed/37703667
http://dx.doi.org/10.1016/j.redox.2023.102866

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