Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblasts

Bivalent epigenomic regulatory domains containing both activating histone 3 lysine 4 (H3K4me3) and repressive lysine 27 (H3K27me3) trimethylation are associated with key developmental genes. These bivalent domains repress transcription in the absence of differentiation signals but maintain regulator...

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Detalles Bibliográficos
Autores principales: Carrasco, Margarita E., Thaler, Roman, Nardocci, Gino, Dudakovic, Amel, van Wijnen, Andre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506106/
https://www.ncbi.nlm.nih.gov/pubmed/37572850
http://dx.doi.org/10.1016/j.jbc.2023.105155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506106/
https://www.ncbi.nlm.nih.gov/pubmed/37572850
http://dx.doi.org/10.1016/j.jbc.2023.105155

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