Cargando…

Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblasts

Bivalent epigenomic regulatory domains containing both activating histone 3 lysine 4 (H3K4me3) and repressive lysine 27 (H3K27me3) trimethylation are associated with key developmental genes. These bivalent domains repress transcription in the absence of differentiation signals but maintain regulator...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carrasco, Margarita E., Thaler, Roman, Nardocci, Gino, Dudakovic, Amel, van Wijnen, Andre J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506106/ https://www.ncbi.nlm.nih.gov/pubmed/37572850 http://dx.doi.org/10.1016/j.jbc.2023.105155

Ejemplares similares

Brd4 Inactivation Increases Adenoviral Delivery of BMP2 for Paracrine Stimulation of Osteogenic Differentiation as a Gene Therapeutic Concept to Enhance Bone Healing
por: Paradise, Christopher R, et al.
Publicado: (2021)

Osteogenic Stimulation of Human Adipose‐Derived Mesenchymal Stem Cells Using a Fungal Metabolite That Suppresses the Polycomb Group Protein EZH2
por: Samsonraj, Rebekah M., et al.
Publicado: (2017)

Lysine-Specific Demethylase 1 (LSD1) epigenetically controls osteoblast differentiation
por: Rummukainen, Petri, et al.
Publicado: (2022)

Redistribution of EZH2 promotes malignant phenotypes by rewiring developmental programmes
por: Mortimer, Thomas, et al.
Publicado: (2019)

Epigenetic Control of Osteogenic Lineage Commitment
por: Montecino, Martin, et al.
Publicado: (2021)

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome
por: Aoyama, Kazumasa, et al.
Publicado: (2018)

Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma
por: Davis, Jennifer L., et al.
Publicado: (2021)

Dynamic redistribution of paxillin in bovine osteoblasts stimulated with adenosine 5′-triphosphate
por: Silber, Ann-Sophie, et al.
Publicado: (2012)

2559 Role of tissue non-specific alkaline phosphatase (TNAP) in promoting the survival of acute myeloid leukemia (AML) cells within the bone marrow microenvironment
por: Bowles, Bradley, et al.
Publicado: (2018)

SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
por: Sun, Jun, et al.
Publicado: (2021)

Intra-articular celecoxib improves knee extension regardless of surgical release in a rabbit model of arthrofibrosis
por: Trousdale, William H., et al.
Publicado: (2022)

Downregulation of the Polycomb-Associated Methyltransferase Ezh2 during Maturation of Hippocampal Neurons Is Mediated by MicroRNAs Let-7 and miR-124
por: Guajardo, Laura, et al.
Publicado: (2020)

Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion
por: Jalan-Sakrikar, Nidhi, et al.
Publicado: (2016)

The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes
por: Beacon, Tasnim H., et al.
Publicado: (2021)

Colocalization and Redistribution of Dishevelled and Actin during WNT-Induced Mesenchymal Morphogenesis
por: Torres, Monica A., et al.
Publicado: (2000)

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells
por: Lima-Fernandes, Evelyne, et al.
Publicado: (2019)

Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures
por: Maria, Sifat, et al.
Publicado: (2017)

Hedgehog and WNT Signaling Hubs in Tracheal Morphogenesis
por: Frank, David B., et al.
Publicado: (2019)

Regulation of Osteoblast Metabolism by Wnt Signaling
por: Moorer, Megan C., et al.
Publicado: (2018)

Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells
por: Morhayim, Jess, et al.
Publicado: (2016)

Heterogeneous Redistribution of Facial Subcategory Information Within and Outside the Face-Selective Domain in Primate Inferior Temporal Cortex
por: Miyakawa, Naohisa, et al.
Publicado: (2018)

Hedgehog Signaling in Tumor Cells Facilitates Osteoblast-Enhanced Osteolytic Metastases
por: Das, Shamik, et al.
Publicado: (2012)

The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury
por: Deng, Chaonan, et al.
Publicado: (2021)

Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation
por: Zunich, Samantha M, et al.
Publicado: (2012)

Generation of bivalent chromatin domains during cell fate decisions
por: De Gobbi, Marco, et al.
Publicado: (2011)

Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis
por: Chen, Jiahuan, et al.
Publicado: (2020)

Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation
por: Zunich, Samantha M, et al.
Publicado: (2009)

Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy
por: Hu, Zhanying, et al.
Publicado: (2019)

Lamin A/C Is Dispensable to Mechanical Repression of Adipogenesis
por: Goelzer, Matthew, et al.
Publicado: (2021)

Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance
por: Avilés, Evelyn C., et al.
Publicado: (2013)

From top to bottom: Cell polarity in Hedgehog and Wnt trafficking
por: Gradilla, Ana-Citlali, et al.
Publicado: (2018)

Developmental pathways associated with cancer metastasis: Notch, Wnt, and Hedgehog
por: Nwabo Kamdje, Armel Herve, et al.
Publicado: (2017)

Transnational Solidarity Within the EU: Public Support for Risk-Sharing and Redistribution
por: Reinl, Ann-Kathrin
Publicado: (2022)

Effects of Modulation of the Hedgehog and Notch Signaling Pathways on Osteoblast Differentiation Induced by Titanium with Nanotopography
por: Souza, Paola Gomes, et al.
Publicado: (2023)

Identification of Conserved Regions and Residues within Hedgehog Acyltransferase Critical for Palmitoylation of Sonic Hedgehog
por: Buglino, John A., et al.
Publicado: (2010)

An orienting response is not enough: Bivalency not infrequency causes the bivalency effect
por: Rey-Mermet, Alodie, et al.
Publicado: (2013)

Spatiotemporal Analysis of Osteoblast Morphology and Wnt Signal‐Induced Osteoblast Reactivation during Bone Modeling in Vitro
por: Tsuji, Naoki, et al.
Publicado: (2022)

Wnt and Hedgehog Are Critical Mediators of Cigarette Smoke-Induced Lung Cancer
por: Lemjabbar-Alaoui, Hassan, et al.
Publicado: (2006)

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
por: Kikuchi, Ippei, et al.
Publicado: (2016)

The Role of Glypican-3 in Regulating Wnt, YAP, and Hedgehog in Liver Cancer
por: Kolluri, Aarti, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tep6dimanjusjkebp5i3rns5u5