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Integrating deep mutational scanning and low-throughput mutagenesis data to predict the impact of amino acid variants

BACKGROUND: Evaluating the impact of amino acid variants has been a critical challenge for studying protein function and interpreting genomic data. High-throughput experimental methods like deep mutational scanning (DMS) can measure the effect of large numbers of variants in a target protein, but be...

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Detalles Bibliográficos
Autores principales:	Fu, Yunfan, Bedő, Justin, Papenfuss, Anthony T, Rubin, Alan F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506130/ https://www.ncbi.nlm.nih.gov/pubmed/37721410 http://dx.doi.org/10.1093/gigascience/giad073

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