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TLR8 escapes X chromosome inactivation in human monocytes and CD4(+) T cells

BACKGROUND: Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity and autoimmune pathogenesis. TLR7 and TLR8 are, respectively, encoded by adjacent X-linked genes. We previously established that TLR7 evades X chromos...

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Detalles Bibliográficos
Autores principales:	Youness, Ali, Cenac, Claire, Faz-López, Berenice, Grunenwald, Solange, Barrat, Franck J., Chaumeil, Julie, Mejía, José Enrique, Guéry, Jean-Charles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506212/ https://www.ncbi.nlm.nih.gov/pubmed/37723501 http://dx.doi.org/10.1186/s13293-023-00544-5

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