A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons

BACKGROUND: Motor neurons (MNs), which are primarily affected in amyotrophic lateral sclerosis (ALS), are a specialized type of neurons that are long and non-dividing. Given their unique structure, these cells heavily rely on transport of organelles along their axons and the process of autophagy to...

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Detalles Bibliográficos
Autores principales: Beckers, Jimmy, Tharkeshwar, Arun Kumar, Fumagalli, Laura, Contardo, Matilde, Van Schoor, Evelien, Fazal, Raheem, Thal, Dietmar Rudolf, Chandran, Siddharthan, Mancuso, Renzo, Van Den Bosch, Ludo, Van Damme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506245/
https://www.ncbi.nlm.nih.gov/pubmed/37723585
http://dx.doi.org/10.1186/s40478-023-01648-0

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