Exo-miR-1290-induced by COX-2 overexpression promotes cancer-associated fibroblasts activation and tumor progression by CUL3-Nrf2 pathway in lung adenocarcinoma

BACKGROUND: Cancer-associated fibroblasts (CAFs) are critically involved in tumor progression by maintaining extracellular mesenchyma (ECM) production and improving tumor development. Cyclooxygenase-2 (COX-2) has been proved to promote ECM formation and tumor progression. However, the mechanisms of...

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Detalles Bibliográficos
Autores principales: Bai, Xiaoming, Shao, Jiaofang, Duan, Tinghong, Liu, Xue, Wang, Min, Li, Xuanya, You, Qiang, Zhang, Zhiyuan, Pan, Jinshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506250/
https://www.ncbi.nlm.nih.gov/pubmed/37723559
http://dx.doi.org/10.1186/s12964-023-01268-0

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