Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in male Lewis rats

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OBJECTIVE: Osteoarthritis (OA) is driven by low-grade inflammation, and controlling local inflammation may offer symptomatic relief. Here, we developed an indoleamine 2,3-dioxygenase and galectin-3 fusion protein (IDO-Gal3), where IDO increases the production of local anti-inflammatory metabolites a...

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Detalles Bibliográficos
Autores principales: Partain, Brittany D., Bracho-Sanchez, Evelyn, Farhadi, Shaheen A., Yarmola, Elena G., Keselowsky, Benjamin G., Hudalla, Gregory A., Allen, Kyle D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506271/
https://www.ncbi.nlm.nih.gov/pubmed/37723593
http://dx.doi.org/10.1186/s13075-023-03153-0

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