Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

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BACKGROUND: Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity in cellular signaling networks within the HCC tumor microen...

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Detalles Bibliográficos
Autores principales: Zhang, Shuming, Yuan, Long, Danilova, Ludmila, Mo, Guanglan, Zhu, Qingfeng, Deshpande, Atul, Bell, Alexander T. F., Elisseeff, Jennifer, Popel, Aleksander S., Anders, Robert A., Jaffee, Elizabeth M., Yarchoan, Mark, Fertig, Elana J., Kagohara, Luciane T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506285/
https://www.ncbi.nlm.nih.gov/pubmed/37723590
http://dx.doi.org/10.1186/s13073-023-01218-y
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