Dysregulation of inflammasome activation in glioma

Gliomas are the most common brain tumors characterized by complicated heterogeneity. The genetic, molecular, and histological pathology of gliomas is characterized by high neuro-inflammation. The inflammatory microenvironment in the central nervous system (CNS) has been closely linked with inflammas...

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Autores principales: Sim, JeongMin, Park, JeongMan, Moon, Jong-Seok, Lim, Jaejoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506313/
https://www.ncbi.nlm.nih.gov/pubmed/37723542
http://dx.doi.org/10.1186/s12964-023-01255-5
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author Sim, JeongMin
Park, JeongMan
Moon, Jong-Seok
Lim, Jaejoon
author_facet Sim, JeongMin
Park, JeongMan
Moon, Jong-Seok
Lim, Jaejoon
author_sort Sim, JeongMin
collection PubMed
description Gliomas are the most common brain tumors characterized by complicated heterogeneity. The genetic, molecular, and histological pathology of gliomas is characterized by high neuro-inflammation. The inflammatory microenvironment in the central nervous system (CNS) has been closely linked with inflammasomes that control the inflammatory response and coordinate innate host defenses. Dysregulation of the inflammasome causes an abnormal inflammatory response, leading to carcinogenesis in glioma. Because of the clinical importance of the various physiological properties of the inflammasome in glioma, the inflammasome has been suggested as a promising treatment target for glioma management. Here, we summarize the current knowledge on the contribution of the inflammasomes in glioma and therapeutic insights. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01255-5.
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spelling pubmed-105063132023-09-19 Dysregulation of inflammasome activation in glioma Sim, JeongMin Park, JeongMan Moon, Jong-Seok Lim, Jaejoon Cell Commun Signal Review Gliomas are the most common brain tumors characterized by complicated heterogeneity. The genetic, molecular, and histological pathology of gliomas is characterized by high neuro-inflammation. The inflammatory microenvironment in the central nervous system (CNS) has been closely linked with inflammasomes that control the inflammatory response and coordinate innate host defenses. Dysregulation of the inflammasome causes an abnormal inflammatory response, leading to carcinogenesis in glioma. Because of the clinical importance of the various physiological properties of the inflammasome in glioma, the inflammasome has been suggested as a promising treatment target for glioma management. Here, we summarize the current knowledge on the contribution of the inflammasomes in glioma and therapeutic insights. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01255-5. BioMed Central 2023-09-18 /pmc/articles/PMC10506313/ /pubmed/37723542 http://dx.doi.org/10.1186/s12964-023-01255-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Sim, JeongMin
Park, JeongMan
Moon, Jong-Seok
Lim, Jaejoon
Dysregulation of inflammasome activation in glioma
title Dysregulation of inflammasome activation in glioma
title_full Dysregulation of inflammasome activation in glioma
title_fullStr Dysregulation of inflammasome activation in glioma
title_full_unstemmed Dysregulation of inflammasome activation in glioma
title_short Dysregulation of inflammasome activation in glioma
title_sort dysregulation of inflammasome activation in glioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506313/
https://www.ncbi.nlm.nih.gov/pubmed/37723542
http://dx.doi.org/10.1186/s12964-023-01255-5
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