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Role of dopamine in the pathophysiology of Parkinson’s disease
A pathological feature of Parkinson’s disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. DA is the neurotransmitter of dopaminergic neurons. Accumulating evidence suggests that DA interacts with environ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506345/ https://www.ncbi.nlm.nih.gov/pubmed/37718439 http://dx.doi.org/10.1186/s40035-023-00378-6 |
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author | Zhou, Zhi Dong Yi, Ling Xiao Wang, Dennis Qing Lim, Tit Meng Tan, Eng King |
author_facet | Zhou, Zhi Dong Yi, Ling Xiao Wang, Dennis Qing Lim, Tit Meng Tan, Eng King |
author_sort | Zhou, Zhi Dong |
collection | PubMed |
description | A pathological feature of Parkinson’s disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. DA is the neurotransmitter of dopaminergic neurons. Accumulating evidence suggests that DA interacts with environmental and genetic factors to contribute to PD pathophysiology. Disturbances of DA synthesis, storage, transportation and metabolism have been shown to promote neurodegeneration of dopaminergic neurons in various PD models. DA is unstable and can undergo oxidation and metabolism to produce multiple reactive and toxic by-products, including reactive oxygen species, DA quinones, and 3,4-dihydroxyphenylacetaldehyde. Here we summarize and highlight recent discoveries on DA-linked pathophysiologic pathways, and discuss the potential protective and therapeutic strategies to mitigate the complications associated with DA. |
format | Online Article Text |
id | pubmed-10506345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105063452023-09-19 Role of dopamine in the pathophysiology of Parkinson’s disease Zhou, Zhi Dong Yi, Ling Xiao Wang, Dennis Qing Lim, Tit Meng Tan, Eng King Transl Neurodegener Review A pathological feature of Parkinson’s disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. DA is the neurotransmitter of dopaminergic neurons. Accumulating evidence suggests that DA interacts with environmental and genetic factors to contribute to PD pathophysiology. Disturbances of DA synthesis, storage, transportation and metabolism have been shown to promote neurodegeneration of dopaminergic neurons in various PD models. DA is unstable and can undergo oxidation and metabolism to produce multiple reactive and toxic by-products, including reactive oxygen species, DA quinones, and 3,4-dihydroxyphenylacetaldehyde. Here we summarize and highlight recent discoveries on DA-linked pathophysiologic pathways, and discuss the potential protective and therapeutic strategies to mitigate the complications associated with DA. BioMed Central 2023-09-18 /pmc/articles/PMC10506345/ /pubmed/37718439 http://dx.doi.org/10.1186/s40035-023-00378-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zhou, Zhi Dong Yi, Ling Xiao Wang, Dennis Qing Lim, Tit Meng Tan, Eng King Role of dopamine in the pathophysiology of Parkinson’s disease |
title | Role of dopamine in the pathophysiology of Parkinson’s disease |
title_full | Role of dopamine in the pathophysiology of Parkinson’s disease |
title_fullStr | Role of dopamine in the pathophysiology of Parkinson’s disease |
title_full_unstemmed | Role of dopamine in the pathophysiology of Parkinson’s disease |
title_short | Role of dopamine in the pathophysiology of Parkinson’s disease |
title_sort | role of dopamine in the pathophysiology of parkinson’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506345/ https://www.ncbi.nlm.nih.gov/pubmed/37718439 http://dx.doi.org/10.1186/s40035-023-00378-6 |
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