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Triggered: Discovery of Neurocysticercosis Following Self-Administered Albendazole
A 25-year-old man with no medical history presented with a seizure one month after taking a self-administered dose of albendazole. Magnetic resonance imaging (MRI) of the brain revealed multiple ring-enhancing lesions, and the workup confirmed neurocysticercosis (NCC). Treatment with antiparasitics...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506364/ https://www.ncbi.nlm.nih.gov/pubmed/37727167 http://dx.doi.org/10.7759/cureus.43746 |
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author | Southall, William R Southall, Madelaine S Aldaas, Mohamad B Sagi, Vishwanath Akella, Phani V |
author_facet | Southall, William R Southall, Madelaine S Aldaas, Mohamad B Sagi, Vishwanath Akella, Phani V |
author_sort | Southall, William R |
collection | PubMed |
description | A 25-year-old man with no medical history presented with a seizure one month after taking a self-administered dose of albendazole. Magnetic resonance imaging (MRI) of the brain revealed multiple ring-enhancing lesions, and the workup confirmed neurocysticercosis (NCC). Treatment with antiparasitics was delayed due to concern for worsening symptoms from the presence of cysts in the midbrain and hippocampus. The balance between treating NCC and limiting cerebral inflammation is delicate and relies on judgment from a multispecialty clinical team. In this case, corticosteroids and antiepileptics alone prevented additional seizures but failed to reduce the overall inflammation of cysts and the progression of the disease. Evidence of new cysts on MRI at week 13 from the onset of symptoms was evidence of an acute, evolving infectious process. Treatment with albendazole and praziquantel was initiated at 13 weeks from the onset of symptoms, and by 31 weeks, nearly all cysts had resolved with minimal residual inflammation. |
format | Online Article Text |
id | pubmed-10506364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-105063642023-09-19 Triggered: Discovery of Neurocysticercosis Following Self-Administered Albendazole Southall, William R Southall, Madelaine S Aldaas, Mohamad B Sagi, Vishwanath Akella, Phani V Cureus Neurology A 25-year-old man with no medical history presented with a seizure one month after taking a self-administered dose of albendazole. Magnetic resonance imaging (MRI) of the brain revealed multiple ring-enhancing lesions, and the workup confirmed neurocysticercosis (NCC). Treatment with antiparasitics was delayed due to concern for worsening symptoms from the presence of cysts in the midbrain and hippocampus. The balance between treating NCC and limiting cerebral inflammation is delicate and relies on judgment from a multispecialty clinical team. In this case, corticosteroids and antiepileptics alone prevented additional seizures but failed to reduce the overall inflammation of cysts and the progression of the disease. Evidence of new cysts on MRI at week 13 from the onset of symptoms was evidence of an acute, evolving infectious process. Treatment with albendazole and praziquantel was initiated at 13 weeks from the onset of symptoms, and by 31 weeks, nearly all cysts had resolved with minimal residual inflammation. Cureus 2023-08-19 /pmc/articles/PMC10506364/ /pubmed/37727167 http://dx.doi.org/10.7759/cureus.43746 Text en Copyright © 2023, Southall et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Neurology Southall, William R Southall, Madelaine S Aldaas, Mohamad B Sagi, Vishwanath Akella, Phani V Triggered: Discovery of Neurocysticercosis Following Self-Administered Albendazole |
title | Triggered: Discovery of Neurocysticercosis Following Self-Administered Albendazole |
title_full | Triggered: Discovery of Neurocysticercosis Following Self-Administered Albendazole |
title_fullStr | Triggered: Discovery of Neurocysticercosis Following Self-Administered Albendazole |
title_full_unstemmed | Triggered: Discovery of Neurocysticercosis Following Self-Administered Albendazole |
title_short | Triggered: Discovery of Neurocysticercosis Following Self-Administered Albendazole |
title_sort | triggered: discovery of neurocysticercosis following self-administered albendazole |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506364/ https://www.ncbi.nlm.nih.gov/pubmed/37727167 http://dx.doi.org/10.7759/cureus.43746 |
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