Cargando…

Deep spatial profiling of Venezuelan equine encephalitis virus reveals increased genetic diversity amidst neuroinflammation and cell death during brain infection

Venezuelan equine encephalitis virus (VEEV) causes a febrile illness that can progress to neurological disease with the possibility of death in human cases. The evaluation and optimization of therapeutics that target brain infections demands knowledge of the host’s response to VEEV, the dynamics of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Williams, Evan P., Xue, Yi, Lee, Jasper, Fitzpatrick, Elizabeth A., Kong, Ying, Reichard, Walter, Writt, Haley, Jonsson, Colleen B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Genetic Diversity and Evolution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506382/ https://www.ncbi.nlm.nih.gov/pubmed/37560924 http://dx.doi.org/10.1128/jvi.00827-23

Ejemplares similares

Emergence and Magnitude of ML336 Resistance in Venezuelan Equine Encephalitis Virus Depend on the Microenvironment
por: Lee, Jasper, et al.
Publicado: (2020)

Characterization of Equine Infectious Anemia Virus Long Terminal Repeat Quasispecies In Vitro and In Vivo
por: Wang, Xue-Feng, et al.
Publicado: (2018)

Spatial-Temporal Patterns of Viral Amplification and Interference Initiated by a Single Infected Cell
por: Akpinar, Fulya, et al.
Publicado: (2016)

Identification of Key Amino Acids in the PB2 and M1 Proteins of H7N9 Influenza Virus That Affect Its Transmission in Guinea Pigs
por: Kong, Huihui, et al.
Publicado: (2019)

Characterization of Clade 7.2 H5 Avian Influenza Viruses That Continue To Circulate in Chickens in China
por: Liu, Liling, et al.
Publicado: (2016)

Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China
por: Liang, Libin, et al.
Publicado: (2016)

Unfixed Endogenous Retroviral Insertions in the Human Population
por: Marchi, Emanuele, et al.
Publicado: (2014)

Deep Sequencing of Norovirus Genomes Defines Evolutionary Patterns in an Urban Tropical Setting
por: Cotten, Matthew, et al.
Publicado: (2014)

Powerful Sequence Similarity Search Methods and In-Depth Manual Analyses Can Identify Remote Homologs in Many Apparently “Orphan” Viral Proteins
por: Kuchibhatla, Durga B., et al.
Publicado: (2014)

Stability of the Parainfluenza Virus 5 Genome Revealed by Deep Sequencing of Strains Isolated from Different Hosts and following Passage in Cell Culture
por: Rima, Bert K., et al.
Publicado: (2014)

Genome Diversity of Epstein-Barr Virus from Multiple Tumor Types and Normal Infection
por: Palser, Anne L., et al.
Publicado: (2015)

Local Evolutionary Patterns of Human Respiratory Syncytial Virus Derived from Whole-Genome Sequencing
por: Agoti, Charles N., et al.
Publicado: (2015)

Phylodynamics of Enterovirus A71-Associated Hand, Foot, and Mouth Disease in Viet Nam
por: Geoghegan, Jemma L., et al.
Publicado: (2015)

Sinorhizobium meliloti Phage ΦM9 Defines a New Group of T4 Superfamily Phages with Unusual Genomic Features but a Common T=16 Capsid
por: Johnson, Matthew C., et al.
Publicado: (2015)

Novel Denisovan and Neanderthal Retroviruses
por: Lee, Adam, et al.
Publicado: (2014)

Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom
por: Elderfield, Ruth A., et al.
Publicado: (2014)

Evolution of Cocirculating Varicella-Zoster Virus Genotypes during a Chickenpox Outbreak in Guinea-Bissau
por: Depledge, Daniel P., et al.
Publicado: (2014)

Molecular Evolutionary Dynamics of Respiratory Syncytial Virus Group A in Recurrent Epidemics in Coastal Kenya
por: Otieno, James R., et al.
Publicado: (2016)

Increasing Clinical Severity during a Dengue Virus Type 3 Cuban Epidemic: Deep Sequencing of Evolving Viral Populations
por: Rodriguez-Roche, Rosmari, et al.
Publicado: (2016)

Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture In Vitro
por: Murrell, Isa, et al.
Publicado: (2016)

Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae
por: Gjessing, Mona C., et al.
Publicado: (2015)

Molecular Epidemiology and Evolution of Influenza Viruses Circulating within European Swine between 2009 and 2013
por: Watson, Simon J., et al.
Publicado: (2015)

Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification
por: Li, Hui, et al.
Publicado: (2015)

Characterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor
por: Jiang, Xiaowei, et al.
Publicado: (2015)

Successive Respiratory Syncytial Virus Epidemics in Local Populations Arise from Multiple Variant Introductions, Providing Insights into Virus Persistence
por: Agoti, Charles N., et al.
Publicado: (2015)

Characterization of a Novel Hepadnavirus in the White Sucker (Catostomus commersonii) from the Great Lakes Region of the United States
por: Hahn, Cassidy M., et al.
Publicado: (2015)

Ecuador Paraiso Escondido Virus, a New Flavivirus Isolated from New World Sand Flies in Ecuador, Is the First Representative of a Novel Clade in the Genus Flavivirus
por: Alkan, Cigdem, et al.
Publicado: (2015)

Complete Unique Genome Sequence, Expression Profile, and Salivary Gland Tissue Tropism of the Herpesvirus 7 Homolog in Pigtailed Macaques
por: Staheli, Jeannette P., et al.
Publicado: (2016)

Time-Dependent Rate Phenomenon in Viruses
por: Aiewsakun, Pakorn, et al.
Publicado: (2016)

Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification
por: Sobel Leonard, Ashley, et al.
Publicado: (2016)

Evidence for the Introduction, Reassortment, and Persistence of Diverse Influenza A Viruses in Antarctica
por: Hurt, Aeron C., et al.
Publicado: (2016)

Weaker HLA Footprints on HIV in the Unique and Highly Genetically Admixed Host Population of Mexico
por: Soto-Nava, Maribel, et al.
Publicado: (2018)

Heterogeneity of the Epstein-Barr Virus (EBV) Major Internal Repeat Reveals Evolutionary Mechanisms of EBV and a Functional Defect in the Prototype EBV Strain B95-8
por: Ba abdullah, Mohammed M., et al.
Publicado: (2017)

Ancient Evolution and Dispersion of Human Papillomavirus 58 Variants
por: Chen, Zigui, et al.
Publicado: (2017)

Avian Influenza Viruses in Wild Birds: Virus Evolution in a Multihost Ecosystem
por: Venkatesh, Divya, et al.
Publicado: (2018)

Insights into Circovirus Host Range from the Genomic Fossil Record
por: Dennis, Tristan P. W., et al.
Publicado: (2018)

A Novel Marsupial Hepatitis A Virus Corroborates Complex Evolutionary Patterns Shaping the Genus Hepatovirus
por: de Oliveira Carneiro, Ianei, et al.
Publicado: (2018)

Whole-Genome Sequencing and Variant Analysis of Human Papillomavirus 16 Infections
por: van der Weele, Pascal, et al.
Publicado: (2017)

Baculovirus Molecular Evolution via Gene Turnover and Recurrent Positive Selection of Key Genes
por: Hill, Tom, et al.
Publicado: (2017)

Inherited Chromosomally Integrated Human Herpesvirus 6 Genomes Are Ancient, Intact, and Potentially Able To Reactivate from Telomeres
por: Zhang, Enjie, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dhhlqgffkd7lklgvv2m96k85sa