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Do Lymph Node Ratio and Histopathologic Parameters Have Any Prognostic Value in Primary Parotid Gland Carcinomas?

OBJECTIVE: To analyze the demographic characteristics and the pathological results of neck dissection in primary parotid gland (PG) cancer patients, and to investigate the effects of histopathological parameters (perineural invasion, lymphovascular invasion, and extracapsular spread), neck metastasi...

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Autores principales: Özcan, Cengiz, Gür, Harun, İsmi, Onur, Vayisoğlu, Yusuf, Bal, Kemal Koray, Bozdoğan Arpacı, Rabia, Görür, Kemal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506524/
https://www.ncbi.nlm.nih.gov/pubmed/37727816
http://dx.doi.org/10.4274/tao.2023.2023-3-5
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author Özcan, Cengiz
Gür, Harun
İsmi, Onur
Vayisoğlu, Yusuf
Bal, Kemal Koray
Bozdoğan Arpacı, Rabia
Görür, Kemal
author_facet Özcan, Cengiz
Gür, Harun
İsmi, Onur
Vayisoğlu, Yusuf
Bal, Kemal Koray
Bozdoğan Arpacı, Rabia
Görür, Kemal
author_sort Özcan, Cengiz
collection PubMed
description OBJECTIVE: To analyze the demographic characteristics and the pathological results of neck dissection in primary parotid gland (PG) cancer patients, and to investigate the effects of histopathological parameters (perineural invasion, lymphovascular invasion, and extracapsular spread), neck metastasis, stage and lymph node ratio (LNR) on survival. METHODS: Patients who underwent parotidectomy for malignant PG tumors between 2000 and 2019 years were retrospectively reviewed from the medical records. Thirty patients who were treated with parotidectomy and neck dissection were included in the study. Lymph node ratio was calculated as the ratio of the number of metastatic lymph nodes (LN) to the total number of excised LNs. Tumor stage, regional LN metastasis, LNR, perineural invasion, lymphovascular invasion, and extracapsular spread were reviewed for the effects on survival with the Kaplan–Meier analysis. RESULTS: The study included 17 (57%) male and 13 (43%) female patients. Their mean age was 67.93±16.90 years (range, 50–85 years). The average number of the excised LN was 26.03±11.79 (range, 3–50). Mean LNR was 0.16±0.26. The Kaplan–Meier analysis showed that neck metastasis (p=0.001) and LNR (p<0.001) were associated with shorter survival times compared to perineural invasion (p=0.818), lymphovascular invasion (p=0.154), extracapsular spread (p=0.410) and stage (p=0.294). In multivariate COX regression analysis, only LNR had a statistically significant difference (p=0.027) compared to the other parameters. CONCLUSION: The present study suggests that LNR and neck metastasis are associated with shorter survival times in PG cancers. Lymph node ratio can be used as a prognostic marker in these patients.
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spelling pubmed-105065242023-09-19 Do Lymph Node Ratio and Histopathologic Parameters Have Any Prognostic Value in Primary Parotid Gland Carcinomas? Özcan, Cengiz Gür, Harun İsmi, Onur Vayisoğlu, Yusuf Bal, Kemal Koray Bozdoğan Arpacı, Rabia Görür, Kemal Turk Arch Otorhinolaryngol Original Investigation OBJECTIVE: To analyze the demographic characteristics and the pathological results of neck dissection in primary parotid gland (PG) cancer patients, and to investigate the effects of histopathological parameters (perineural invasion, lymphovascular invasion, and extracapsular spread), neck metastasis, stage and lymph node ratio (LNR) on survival. METHODS: Patients who underwent parotidectomy for malignant PG tumors between 2000 and 2019 years were retrospectively reviewed from the medical records. Thirty patients who were treated with parotidectomy and neck dissection were included in the study. Lymph node ratio was calculated as the ratio of the number of metastatic lymph nodes (LN) to the total number of excised LNs. Tumor stage, regional LN metastasis, LNR, perineural invasion, lymphovascular invasion, and extracapsular spread were reviewed for the effects on survival with the Kaplan–Meier analysis. RESULTS: The study included 17 (57%) male and 13 (43%) female patients. Their mean age was 67.93±16.90 years (range, 50–85 years). The average number of the excised LN was 26.03±11.79 (range, 3–50). Mean LNR was 0.16±0.26. The Kaplan–Meier analysis showed that neck metastasis (p=0.001) and LNR (p<0.001) were associated with shorter survival times compared to perineural invasion (p=0.818), lymphovascular invasion (p=0.154), extracapsular spread (p=0.410) and stage (p=0.294). In multivariate COX regression analysis, only LNR had a statistically significant difference (p=0.027) compared to the other parameters. CONCLUSION: The present study suggests that LNR and neck metastasis are associated with shorter survival times in PG cancers. Lymph node ratio can be used as a prognostic marker in these patients. Galenos Publishing 2023-06 2023-09-18 /pmc/articles/PMC10506524/ /pubmed/37727816 http://dx.doi.org/10.4274/tao.2023.2023-3-5 Text en ©Copyright 2023 by Turkish Otorhinolaryngology-Head and Neck Surgery Society / Turkish Archives of Otorhinolaryngology is published by Galenos Publishing House https://creativecommons.org/licenses/by-nc/4.0/Licenced under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
spellingShingle Original Investigation
Özcan, Cengiz
Gür, Harun
İsmi, Onur
Vayisoğlu, Yusuf
Bal, Kemal Koray
Bozdoğan Arpacı, Rabia
Görür, Kemal
Do Lymph Node Ratio and Histopathologic Parameters Have Any Prognostic Value in Primary Parotid Gland Carcinomas?
title Do Lymph Node Ratio and Histopathologic Parameters Have Any Prognostic Value in Primary Parotid Gland Carcinomas?
title_full Do Lymph Node Ratio and Histopathologic Parameters Have Any Prognostic Value in Primary Parotid Gland Carcinomas?
title_fullStr Do Lymph Node Ratio and Histopathologic Parameters Have Any Prognostic Value in Primary Parotid Gland Carcinomas?
title_full_unstemmed Do Lymph Node Ratio and Histopathologic Parameters Have Any Prognostic Value in Primary Parotid Gland Carcinomas?
title_short Do Lymph Node Ratio and Histopathologic Parameters Have Any Prognostic Value in Primary Parotid Gland Carcinomas?
title_sort do lymph node ratio and histopathologic parameters have any prognostic value in primary parotid gland carcinomas?
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506524/
https://www.ncbi.nlm.nih.gov/pubmed/37727816
http://dx.doi.org/10.4274/tao.2023.2023-3-5
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