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How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation—A simulated study

Neglected tropical diseases (NTDs) largely impact marginalised communities living in tropical and subtropical regions. Mass drug administration is the leading intervention method for five NTDs; however, it is known that there is lack of access to treatment for some populations and demographic groups...

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Autores principales: Clark, Jessica, Davis, Emma L., Prada, Joaquin M., Gass, Katherine, Krentel, Alison, Hollingsworth, T. Déirdre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506705/
https://www.ncbi.nlm.nih.gov/pubmed/37672518
http://dx.doi.org/10.1371/journal.pntd.0011582
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author Clark, Jessica
Davis, Emma L.
Prada, Joaquin M.
Gass, Katherine
Krentel, Alison
Hollingsworth, T. Déirdre
author_facet Clark, Jessica
Davis, Emma L.
Prada, Joaquin M.
Gass, Katherine
Krentel, Alison
Hollingsworth, T. Déirdre
author_sort Clark, Jessica
collection PubMed
description Neglected tropical diseases (NTDs) largely impact marginalised communities living in tropical and subtropical regions. Mass drug administration is the leading intervention method for five NTDs; however, it is known that there is lack of access to treatment for some populations and demographic groups. It is also likely that those individuals without access to treatment are excluded from surveillance. It is important to consider the impacts of this on the overall success, and monitoring and evaluation (M&E) of intervention programmes. We use a detailed individual-based model of the infection dynamics of lymphatic filariasis to investigate the impact of excluded, untreated, and therefore unobserved groups on the true versus observed infection dynamics and subsequent intervention success. We simulate surveillance in four groups–the whole population eligible to receive treatment, the whole eligible population with access to treatment, the TAS focus of six- and seven-year-olds, and finally in >20-year-olds. We show that the surveillance group under observation has a significant impact on perceived dynamics. Exclusion to treatment and surveillance negatively impacts the probability of reaching public health goals, though in populations that do reach these goals there are no signals to indicate excluded groups. Increasingly restricted surveillance groups over-estimate the efficacy of MDA. The presence of non-treated groups cannot be inferred when surveillance is only occurring in the group receiving treatment.
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spelling pubmed-105067052023-09-19 How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation—A simulated study Clark, Jessica Davis, Emma L. Prada, Joaquin M. Gass, Katherine Krentel, Alison Hollingsworth, T. Déirdre PLoS Negl Trop Dis Research Article Neglected tropical diseases (NTDs) largely impact marginalised communities living in tropical and subtropical regions. Mass drug administration is the leading intervention method for five NTDs; however, it is known that there is lack of access to treatment for some populations and demographic groups. It is also likely that those individuals without access to treatment are excluded from surveillance. It is important to consider the impacts of this on the overall success, and monitoring and evaluation (M&E) of intervention programmes. We use a detailed individual-based model of the infection dynamics of lymphatic filariasis to investigate the impact of excluded, untreated, and therefore unobserved groups on the true versus observed infection dynamics and subsequent intervention success. We simulate surveillance in four groups–the whole population eligible to receive treatment, the whole eligible population with access to treatment, the TAS focus of six- and seven-year-olds, and finally in >20-year-olds. We show that the surveillance group under observation has a significant impact on perceived dynamics. Exclusion to treatment and surveillance negatively impacts the probability of reaching public health goals, though in populations that do reach these goals there are no signals to indicate excluded groups. Increasingly restricted surveillance groups over-estimate the efficacy of MDA. The presence of non-treated groups cannot be inferred when surveillance is only occurring in the group receiving treatment. Public Library of Science 2023-09-06 /pmc/articles/PMC10506705/ /pubmed/37672518 http://dx.doi.org/10.1371/journal.pntd.0011582 Text en © 2023 Clark et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Clark, Jessica
Davis, Emma L.
Prada, Joaquin M.
Gass, Katherine
Krentel, Alison
Hollingsworth, T. Déirdre
How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation—A simulated study
title How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation—A simulated study
title_full How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation—A simulated study
title_fullStr How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation—A simulated study
title_full_unstemmed How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation—A simulated study
title_short How correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation—A simulated study
title_sort how correlations between treatment access and surveillance inclusion impact neglected tropical disease monitoring and evaluation—a simulated study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506705/
https://www.ncbi.nlm.nih.gov/pubmed/37672518
http://dx.doi.org/10.1371/journal.pntd.0011582
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