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HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019
Voluntary medical male circumcision (VMMC) has primarily been promoted for HIV prevention. Evidence also supports that male circumcision offers protection against other sexually transmitted infections. This analysis assessed the effect of circumcision on syphilis, hepatitis B virus (HBV) infection a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506706/ https://www.ncbi.nlm.nih.gov/pubmed/37721926 http://dx.doi.org/10.1371/journal.pgph.0002326 |
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author | Peck, Megan E. Bronson, Megan Djomand, Gaston Basile, Ikuzo Collins, Kamanzi Kankindi, Ida Kayirangwa, Eugenie Malamba, Samuel S. Mugisha, Veronicah Nsanzimana, Sabin Remera, Eric Kazaura, Kokuhumbya J. Amuri, Mbaraka Mmbando, Susan Mgomella, George S. Simbeye, Daimon Colletar Awor, Anna Biraro, Samuel Kabuye, Geoffrey Kirungi, Wilford Chituwo, Omega Hanunka, Brave Kamboyi, Royd Mulenga, Lloyd Musonda, Bupe Muyunda, Brian Nkumbula, Tepa Malaba, Rickie Mandisarisa, John Musuka, Godfrey Peterson, Amy E. Toledo, Carlos |
author_facet | Peck, Megan E. Bronson, Megan Djomand, Gaston Basile, Ikuzo Collins, Kamanzi Kankindi, Ida Kayirangwa, Eugenie Malamba, Samuel S. Mugisha, Veronicah Nsanzimana, Sabin Remera, Eric Kazaura, Kokuhumbya J. Amuri, Mbaraka Mmbando, Susan Mgomella, George S. Simbeye, Daimon Colletar Awor, Anna Biraro, Samuel Kabuye, Geoffrey Kirungi, Wilford Chituwo, Omega Hanunka, Brave Kamboyi, Royd Mulenga, Lloyd Musonda, Bupe Muyunda, Brian Nkumbula, Tepa Malaba, Rickie Mandisarisa, John Musuka, Godfrey Peterson, Amy E. Toledo, Carlos |
author_sort | Peck, Megan E. |
collection | PubMed |
description | Voluntary medical male circumcision (VMMC) has primarily been promoted for HIV prevention. Evidence also supports that male circumcision offers protection against other sexually transmitted infections. This analysis assessed the effect of circumcision on syphilis, hepatitis B virus (HBV) infection and HIV. Data from the 2015 to 2019 Population-based HIV Impact Assessments (PHIAs) surveys from Rwanda, Tanzania, Uganda, Zambia, and Zimbabwe were used for the analysis. The PHIA surveys are cross-sectional, nationally representative household surveys that include biomarking testing for HIV, syphilis and HBV infection. This is a secondary data analysis using publicly available PHIA data. Univariate and multivariable logistic regression models were created using pooled PHIA data across the five countries to assess the effect of male circumcision on HIV, active and ever syphilis, and HBV infection among sexually active males aged 15–59 years. Circumcised men had lower odds of syphilis infection, ever or active infection, and HIV, compared to uncircumcised men, after adjusting for covariates (active syphilis infection = 0.67 adjusted odds ratio (aOR), 95% confidence interval (CI), 0.52–0.87, ever having had a syphilis infection = 0.85 aOR, 95% CI, 0.73–0.98, and HIV = 0.53 aOR, 95% CI, 0.47–0.61). No difference between circumcised and uncircumcised men was identified for HBV infection (P = 0.75). Circumcised men have a reduced likelihood for syphilis and HIV compared to uncircumcised men. However, we found no statistically significant difference between circumcised and uncircumcised men for HBV infection. |
format | Online Article Text |
id | pubmed-10506706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-105067062023-09-19 HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019 Peck, Megan E. Bronson, Megan Djomand, Gaston Basile, Ikuzo Collins, Kamanzi Kankindi, Ida Kayirangwa, Eugenie Malamba, Samuel S. Mugisha, Veronicah Nsanzimana, Sabin Remera, Eric Kazaura, Kokuhumbya J. Amuri, Mbaraka Mmbando, Susan Mgomella, George S. Simbeye, Daimon Colletar Awor, Anna Biraro, Samuel Kabuye, Geoffrey Kirungi, Wilford Chituwo, Omega Hanunka, Brave Kamboyi, Royd Mulenga, Lloyd Musonda, Bupe Muyunda, Brian Nkumbula, Tepa Malaba, Rickie Mandisarisa, John Musuka, Godfrey Peterson, Amy E. Toledo, Carlos PLOS Glob Public Health Research Article Voluntary medical male circumcision (VMMC) has primarily been promoted for HIV prevention. Evidence also supports that male circumcision offers protection against other sexually transmitted infections. This analysis assessed the effect of circumcision on syphilis, hepatitis B virus (HBV) infection and HIV. Data from the 2015 to 2019 Population-based HIV Impact Assessments (PHIAs) surveys from Rwanda, Tanzania, Uganda, Zambia, and Zimbabwe were used for the analysis. The PHIA surveys are cross-sectional, nationally representative household surveys that include biomarking testing for HIV, syphilis and HBV infection. This is a secondary data analysis using publicly available PHIA data. Univariate and multivariable logistic regression models were created using pooled PHIA data across the five countries to assess the effect of male circumcision on HIV, active and ever syphilis, and HBV infection among sexually active males aged 15–59 years. Circumcised men had lower odds of syphilis infection, ever or active infection, and HIV, compared to uncircumcised men, after adjusting for covariates (active syphilis infection = 0.67 adjusted odds ratio (aOR), 95% confidence interval (CI), 0.52–0.87, ever having had a syphilis infection = 0.85 aOR, 95% CI, 0.73–0.98, and HIV = 0.53 aOR, 95% CI, 0.47–0.61). No difference between circumcised and uncircumcised men was identified for HBV infection (P = 0.75). Circumcised men have a reduced likelihood for syphilis and HIV compared to uncircumcised men. However, we found no statistically significant difference between circumcised and uncircumcised men for HBV infection. Public Library of Science 2023-09-18 /pmc/articles/PMC10506706/ /pubmed/37721926 http://dx.doi.org/10.1371/journal.pgph.0002326 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
spellingShingle | Research Article Peck, Megan E. Bronson, Megan Djomand, Gaston Basile, Ikuzo Collins, Kamanzi Kankindi, Ida Kayirangwa, Eugenie Malamba, Samuel S. Mugisha, Veronicah Nsanzimana, Sabin Remera, Eric Kazaura, Kokuhumbya J. Amuri, Mbaraka Mmbando, Susan Mgomella, George S. Simbeye, Daimon Colletar Awor, Anna Biraro, Samuel Kabuye, Geoffrey Kirungi, Wilford Chituwo, Omega Hanunka, Brave Kamboyi, Royd Mulenga, Lloyd Musonda, Bupe Muyunda, Brian Nkumbula, Tepa Malaba, Rickie Mandisarisa, John Musuka, Godfrey Peterson, Amy E. Toledo, Carlos HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019 |
title | HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019 |
title_full | HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019 |
title_fullStr | HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019 |
title_full_unstemmed | HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019 |
title_short | HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019 |
title_sort | hiv, syphilis, and hepatitis b virus infection and male circumcision in five sub-saharan african countries: findings from the population-based hiv impact assessment surveys, 2015–2019 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506706/ https://www.ncbi.nlm.nih.gov/pubmed/37721926 http://dx.doi.org/10.1371/journal.pgph.0002326 |
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