Cargando…

HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019

Voluntary medical male circumcision (VMMC) has primarily been promoted for HIV prevention. Evidence also supports that male circumcision offers protection against other sexually transmitted infections. This analysis assessed the effect of circumcision on syphilis, hepatitis B virus (HBV) infection a...

Descripción completa

Detalles Bibliográficos
Autores principales: Peck, Megan E., Bronson, Megan, Djomand, Gaston, Basile, Ikuzo, Collins, Kamanzi, Kankindi, Ida, Kayirangwa, Eugenie, Malamba, Samuel S., Mugisha, Veronicah, Nsanzimana, Sabin, Remera, Eric, Kazaura, Kokuhumbya J., Amuri, Mbaraka, Mmbando, Susan, Mgomella, George S., Simbeye, Daimon, Colletar Awor, Anna, Biraro, Samuel, Kabuye, Geoffrey, Kirungi, Wilford, Chituwo, Omega, Hanunka, Brave, Kamboyi, Royd, Mulenga, Lloyd, Musonda, Bupe, Muyunda, Brian, Nkumbula, Tepa, Malaba, Rickie, Mandisarisa, John, Musuka, Godfrey, Peterson, Amy E., Toledo, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506706/
https://www.ncbi.nlm.nih.gov/pubmed/37721926
http://dx.doi.org/10.1371/journal.pgph.0002326
_version_ 1785107160372346880
author Peck, Megan E.
Bronson, Megan
Djomand, Gaston
Basile, Ikuzo
Collins, Kamanzi
Kankindi, Ida
Kayirangwa, Eugenie
Malamba, Samuel S.
Mugisha, Veronicah
Nsanzimana, Sabin
Remera, Eric
Kazaura, Kokuhumbya J.
Amuri, Mbaraka
Mmbando, Susan
Mgomella, George S.
Simbeye, Daimon
Colletar Awor, Anna
Biraro, Samuel
Kabuye, Geoffrey
Kirungi, Wilford
Chituwo, Omega
Hanunka, Brave
Kamboyi, Royd
Mulenga, Lloyd
Musonda, Bupe
Muyunda, Brian
Nkumbula, Tepa
Malaba, Rickie
Mandisarisa, John
Musuka, Godfrey
Peterson, Amy E.
Toledo, Carlos
author_facet Peck, Megan E.
Bronson, Megan
Djomand, Gaston
Basile, Ikuzo
Collins, Kamanzi
Kankindi, Ida
Kayirangwa, Eugenie
Malamba, Samuel S.
Mugisha, Veronicah
Nsanzimana, Sabin
Remera, Eric
Kazaura, Kokuhumbya J.
Amuri, Mbaraka
Mmbando, Susan
Mgomella, George S.
Simbeye, Daimon
Colletar Awor, Anna
Biraro, Samuel
Kabuye, Geoffrey
Kirungi, Wilford
Chituwo, Omega
Hanunka, Brave
Kamboyi, Royd
Mulenga, Lloyd
Musonda, Bupe
Muyunda, Brian
Nkumbula, Tepa
Malaba, Rickie
Mandisarisa, John
Musuka, Godfrey
Peterson, Amy E.
Toledo, Carlos
author_sort Peck, Megan E.
collection PubMed
description Voluntary medical male circumcision (VMMC) has primarily been promoted for HIV prevention. Evidence also supports that male circumcision offers protection against other sexually transmitted infections. This analysis assessed the effect of circumcision on syphilis, hepatitis B virus (HBV) infection and HIV. Data from the 2015 to 2019 Population-based HIV Impact Assessments (PHIAs) surveys from Rwanda, Tanzania, Uganda, Zambia, and Zimbabwe were used for the analysis. The PHIA surveys are cross-sectional, nationally representative household surveys that include biomarking testing for HIV, syphilis and HBV infection. This is a secondary data analysis using publicly available PHIA data. Univariate and multivariable logistic regression models were created using pooled PHIA data across the five countries to assess the effect of male circumcision on HIV, active and ever syphilis, and HBV infection among sexually active males aged 15–59 years. Circumcised men had lower odds of syphilis infection, ever or active infection, and HIV, compared to uncircumcised men, after adjusting for covariates (active syphilis infection = 0.67 adjusted odds ratio (aOR), 95% confidence interval (CI), 0.52–0.87, ever having had a syphilis infection = 0.85 aOR, 95% CI, 0.73–0.98, and HIV = 0.53 aOR, 95% CI, 0.47–0.61). No difference between circumcised and uncircumcised men was identified for HBV infection (P = 0.75). Circumcised men have a reduced likelihood for syphilis and HIV compared to uncircumcised men. However, we found no statistically significant difference between circumcised and uncircumcised men for HBV infection.
format Online
Article
Text
id pubmed-10506706
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-105067062023-09-19 HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019 Peck, Megan E. Bronson, Megan Djomand, Gaston Basile, Ikuzo Collins, Kamanzi Kankindi, Ida Kayirangwa, Eugenie Malamba, Samuel S. Mugisha, Veronicah Nsanzimana, Sabin Remera, Eric Kazaura, Kokuhumbya J. Amuri, Mbaraka Mmbando, Susan Mgomella, George S. Simbeye, Daimon Colletar Awor, Anna Biraro, Samuel Kabuye, Geoffrey Kirungi, Wilford Chituwo, Omega Hanunka, Brave Kamboyi, Royd Mulenga, Lloyd Musonda, Bupe Muyunda, Brian Nkumbula, Tepa Malaba, Rickie Mandisarisa, John Musuka, Godfrey Peterson, Amy E. Toledo, Carlos PLOS Glob Public Health Research Article Voluntary medical male circumcision (VMMC) has primarily been promoted for HIV prevention. Evidence also supports that male circumcision offers protection against other sexually transmitted infections. This analysis assessed the effect of circumcision on syphilis, hepatitis B virus (HBV) infection and HIV. Data from the 2015 to 2019 Population-based HIV Impact Assessments (PHIAs) surveys from Rwanda, Tanzania, Uganda, Zambia, and Zimbabwe were used for the analysis. The PHIA surveys are cross-sectional, nationally representative household surveys that include biomarking testing for HIV, syphilis and HBV infection. This is a secondary data analysis using publicly available PHIA data. Univariate and multivariable logistic regression models were created using pooled PHIA data across the five countries to assess the effect of male circumcision on HIV, active and ever syphilis, and HBV infection among sexually active males aged 15–59 years. Circumcised men had lower odds of syphilis infection, ever or active infection, and HIV, compared to uncircumcised men, after adjusting for covariates (active syphilis infection = 0.67 adjusted odds ratio (aOR), 95% confidence interval (CI), 0.52–0.87, ever having had a syphilis infection = 0.85 aOR, 95% CI, 0.73–0.98, and HIV = 0.53 aOR, 95% CI, 0.47–0.61). No difference between circumcised and uncircumcised men was identified for HBV infection (P = 0.75). Circumcised men have a reduced likelihood for syphilis and HIV compared to uncircumcised men. However, we found no statistically significant difference between circumcised and uncircumcised men for HBV infection. Public Library of Science 2023-09-18 /pmc/articles/PMC10506706/ /pubmed/37721926 http://dx.doi.org/10.1371/journal.pgph.0002326 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Peck, Megan E.
Bronson, Megan
Djomand, Gaston
Basile, Ikuzo
Collins, Kamanzi
Kankindi, Ida
Kayirangwa, Eugenie
Malamba, Samuel S.
Mugisha, Veronicah
Nsanzimana, Sabin
Remera, Eric
Kazaura, Kokuhumbya J.
Amuri, Mbaraka
Mmbando, Susan
Mgomella, George S.
Simbeye, Daimon
Colletar Awor, Anna
Biraro, Samuel
Kabuye, Geoffrey
Kirungi, Wilford
Chituwo, Omega
Hanunka, Brave
Kamboyi, Royd
Mulenga, Lloyd
Musonda, Bupe
Muyunda, Brian
Nkumbula, Tepa
Malaba, Rickie
Mandisarisa, John
Musuka, Godfrey
Peterson, Amy E.
Toledo, Carlos
HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019
title HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019
title_full HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019
title_fullStr HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019
title_full_unstemmed HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019
title_short HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015–2019
title_sort hiv, syphilis, and hepatitis b virus infection and male circumcision in five sub-saharan african countries: findings from the population-based hiv impact assessment surveys, 2015–2019
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506706/
https://www.ncbi.nlm.nih.gov/pubmed/37721926
http://dx.doi.org/10.1371/journal.pgph.0002326
work_keys_str_mv AT peckmegane hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT bronsonmegan hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT djomandgaston hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT basileikuzo hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT collinskamanzi hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT kankindiida hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT kayirangwaeugenie hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT malambasamuels hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT mugishaveronicah hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT nsanzimanasabin hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT remeraeric hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT kazaurakokuhumbyaj hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT amurimbaraka hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT mmbandosusan hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT mgomellageorges hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT simbeyedaimon hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT colletaraworanna hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT birarosamuel hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT kabuyegeoffrey hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT kirungiwilford hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT chituwoomega hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT hanunkabrave hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT kamboyiroyd hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT mulengalloyd hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT musondabupe hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT muyundabrian hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT nkumbulatepa hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT malabarickie hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT mandisarisajohn hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT musukagodfrey hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT petersonamye hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019
AT toledocarlos hivsyphilisandhepatitisbvirusinfectionandmalecircumcisioninfivesubsaharanafricancountriesfindingsfromthepopulationbasedhivimpactassessmentsurveys20152019