Cargando…

Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Healthy Volunteers

BACKGROUND: Dengue is a growing global health threat with no specific antiviral drugs available for treatment or prophylaxis. This first-in-human, double-blind, randomized, placebo-controlled study aimed to examine the safety, tolerability, and pharmacokinetics of increasing single and multiple oral...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ackaert, Oliver, Vanhoutte, Frédéric, Verpoorten, Nathalie, Buelens, Annemie, Lachau-Durand, Sophie, Lammens, Lieve, Hoetelmans, Richard, Van Loock, Marnix, Herrera-Taracena, Guillermo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Major Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506772/ https://www.ncbi.nlm.nih.gov/pubmed/37161721 http://dx.doi.org/10.1093/cid/ciad284

Ejemplares similares

A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships
por: Goethals, Olivia, et al.
Publicado: (2023)

Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients
por: Lachau-Durand, Sophie, et al.
Publicado: (2019)

Bonaparte, 1769-1802 /
por: Gueniffey, Patrice
Publicado: (2018)

Medical Lectures for 1802
Publicado: (1802)

Donald Monro (1727–1802)
Publicado: (1971)

On the Epidemic Distempers of the Year 1802
por: Potter, Nathaniel
Publicado: (1804)

Medical Society, London, 1802
Publicado: (1802)

Paris and its provinces, 1792-1802 /
por: Cobb, Richard, 1917-1996
Publicado: (1975)

Sir Dominic Corrigan [1802-1880]
Publicado: (1925)

Napoleón et sa famille (1769-1802)
por: Masson, Frédéric, 1847-1923
Publicado: (1897)

Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers
por: Postnov, Andrey, et al.
Publicado: (2018)

John Creery Ferguson 1802-1865: Physician and fetologist.
por: Pinkerton, J. H.
Publicado: (1981)

Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534
por: Xue, Xiaohua, et al.
Publicado: (2021)

Safety, tolerability, and pharmacokinetics of an anti-LAG-3 antibody SHR-1802 in patients with advanced solid tumors: a phase I dose-escalation and dose-expansion study
por: Deng, Ting, et al.
Publicado: (2023)

JNJ-64041757 (JNJ-757), a Live, Attenuated, Double-Deleted Listeria monocytogenes–Based Immunotherapy in Patients With NSCLC: Results From Two Phase 1 Studies
por: Brahmer, Julie R., et al.
Publicado: (2020)

Members Admitted Since 1802 into the Royal College of Physicians, Edinburgh
Publicado: (1804)

Report of the Bombay Medical Board, Dated July 2, 1802
por: Moir, W., et al.
Publicado: (1803)

The genus Epeolus Latreille, 1802 (Hymenoptera, Apidae) in Central Asia
por: Astafurova, Yulia V., et al.
Publicado: (2023)

The complete mitochondrial genome of Ceutorhynchus obstrictus (Marsham, 1802) (Coleoptera: Curculionidae)
por: Lee, Hyobin, et al.
Publicado: (2019)

The genome sequence of the plain dark bee, Stelis phaeoptera (Kirby, 1802)
por: Boyes, Clare
Publicado: (2023)

Functional annotation of human cytomegalovirus gene products: an update
por: Van Damme, Ellen, et al.
Publicado: (2014)

JNJ-26481585 primes rhabdomyosarcoma cells for chemotherapeutics by engaging the mitochondrial pathway of apoptosis
por: Heinicke, Ulrike, et al.
Publicado: (2015)

Author Correction: Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534
por: Xue, Xiaohua, et al.
Publicado: (2022)

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET
por: Neijssen, Joost, et al.
Publicado: (2021)

A study on the effect of JNJ-10397049 on proliferation and differentiation of neural precursor cells
por: Karami, Neda, et al.
Publicado: (2022)

Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis
por: Wagner, Frank, et al.
Publicado: (2023)

The life and teaching of William Sharpey (1802-1880) 'Father of Modern Physiology' in Britain.
por: Taylor, D W
Publicado: (1971)

The life and teaching of William Sharpey (1802-1880). 'Father of modern physiology' in Britain.
por: Taylor, D W
Publicado: (1971)

Fantasmas de la luz y el caos 1801 y 1802 /
por: Aguilar Mora, Jorge
Publicado: (2018)

Corrigendum to the Document: ""Draft Council Resolution Concerning the Accession of Finland"" (CERN/1802)
Publicado: (1990)

The genome sequence of the box-headed blood bee, Sphecodes monilicornis (Kirby, 1802)
por: Falk, Steven, et al.
Publicado: (2022)

1802. Reconstructing Twelve Years of Dengue Outbreaks in the Caribbean Using Travel Surveillance
por: Taylor-Salmon, Emma, et al.
Publicado: (2023)

Combining a Universal Capture Ligand and Pan-Serotype Monoclonal Antibody to Develop a Pan-Serotype Lateral Flow Strip Test for Foot-and-Mouth Disease Virus Detection
por: Yang, Ming, et al.
Publicado: (2022)

Topical administration of regorafenib eye drops: phase I dose‐escalation study in healthy volunteers
por: Zimmermann, Torsten, et al.
Publicado: (2018)

A medical student at St Thomas's Hospital, 1801-1802. The Weekes family letters.
por: Ford, J. M.
Publicado: (1987)

Die medizinische Forschung und Lehre an der Universität Dorpat/Tartu 1802-1940
por: Jack, D. B.
Publicado: (1987)

Account of Diseases in an Eastern District of London, from Nov. 20, to Dec. 20, 1802
Publicado: (1803)

Account of Diseases in an Eastern District of London: From February 20, to March 20, 1802
Publicado: (1802)

Account of Diseases in an Eastern District of London: From March 20, to April 20, 1802
Publicado: (1802)

Account of Diseases in an Eastern District of London: From April 20, to May 20, 1802
Publicado: (1802)

Cannot write session to /tmp/vufind_sessions/sess_elj0alqhlem3qms2gfd10chd83