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Mucocutaneous Findings in Hematolymphoid Neoplasms: An Observational Study

BACKGROUND: Cutaneous manifestations of hematological neoplasms can be divided into three broad categories – direct infiltration, paraneoplastic conditions, and those due to the treatment of hematological cancers. OBJECTIVES: To study the frequency and patterns of mucocutaneous manifestations in pat...

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Autores principales: Batra, Anmol, Hazarika, Neirita, Nath, Uttam Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506838/
https://www.ncbi.nlm.nih.gov/pubmed/37727568
http://dx.doi.org/10.4103/idoj.idoj_438_22
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author Batra, Anmol
Hazarika, Neirita
Nath, Uttam Kumar
author_facet Batra, Anmol
Hazarika, Neirita
Nath, Uttam Kumar
author_sort Batra, Anmol
collection PubMed
description BACKGROUND: Cutaneous manifestations of hematological neoplasms can be divided into three broad categories – direct infiltration, paraneoplastic conditions, and those due to the treatment of hematological cancers. OBJECTIVES: To study the frequency and patterns of mucocutaneous manifestations in patients with hematolymphoid neoplasms and those due to chemotherapy. MATERIALS AND METHODS: This was an observational study done with 172 patients. Categorization of mucocutaneous manifestations was done into malignancy-associated and chemotherapeutic drugs-associated and data was analyzed. RESULTS: Out of a total of 172 patients, 15.6% (27/172) had malignancy-related mucocutaneous manifestations. Among these, 4.6% (8/172) had direct infiltration of malignant cells into the skin and 11% (19/172) had paraneoplastic manifestations. The most common chemotherapy-related mucocutaneous manifestations were nail changes – 47.1% (81/172), of which transverse melanonychia was the most common (20.9%). About 44.2% (76/172) had a cutaneous infection, the commonest of which was a fungal infection (15.1%). Chemotherapy-induced alopecia was noted in 46.5% (80/172) and found to be significantly associated with cytarabine, daunorubicin, doxorubicin, methotrexate, and vincristine. Cutaneous hyperpigmentation was found to be significantly associated with cytarabine, doxorubicin, and vincristine. CONCLUSION: Mucocutaneous manifestations cause additional discomfort to a patient undergoing chemotherapy. Early recognition and timely and appropriate management facilitate symptom control and prevent treatment-related morbidity. A multidisciplinary approach involving hemato-oncologists and dermatologists can help achieve this target.
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spelling pubmed-105068382023-09-19 Mucocutaneous Findings in Hematolymphoid Neoplasms: An Observational Study Batra, Anmol Hazarika, Neirita Nath, Uttam Kumar Indian Dermatol Online J Original Article BACKGROUND: Cutaneous manifestations of hematological neoplasms can be divided into three broad categories – direct infiltration, paraneoplastic conditions, and those due to the treatment of hematological cancers. OBJECTIVES: To study the frequency and patterns of mucocutaneous manifestations in patients with hematolymphoid neoplasms and those due to chemotherapy. MATERIALS AND METHODS: This was an observational study done with 172 patients. Categorization of mucocutaneous manifestations was done into malignancy-associated and chemotherapeutic drugs-associated and data was analyzed. RESULTS: Out of a total of 172 patients, 15.6% (27/172) had malignancy-related mucocutaneous manifestations. Among these, 4.6% (8/172) had direct infiltration of malignant cells into the skin and 11% (19/172) had paraneoplastic manifestations. The most common chemotherapy-related mucocutaneous manifestations were nail changes – 47.1% (81/172), of which transverse melanonychia was the most common (20.9%). About 44.2% (76/172) had a cutaneous infection, the commonest of which was a fungal infection (15.1%). Chemotherapy-induced alopecia was noted in 46.5% (80/172) and found to be significantly associated with cytarabine, daunorubicin, doxorubicin, methotrexate, and vincristine. Cutaneous hyperpigmentation was found to be significantly associated with cytarabine, doxorubicin, and vincristine. CONCLUSION: Mucocutaneous manifestations cause additional discomfort to a patient undergoing chemotherapy. Early recognition and timely and appropriate management facilitate symptom control and prevent treatment-related morbidity. A multidisciplinary approach involving hemato-oncologists and dermatologists can help achieve this target. Wolters Kluwer - Medknow 2023-08-29 /pmc/articles/PMC10506838/ /pubmed/37727568 http://dx.doi.org/10.4103/idoj.idoj_438_22 Text en Copyright: © 2023 Indian Dermatology Online Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Batra, Anmol
Hazarika, Neirita
Nath, Uttam Kumar
Mucocutaneous Findings in Hematolymphoid Neoplasms: An Observational Study
title Mucocutaneous Findings in Hematolymphoid Neoplasms: An Observational Study
title_full Mucocutaneous Findings in Hematolymphoid Neoplasms: An Observational Study
title_fullStr Mucocutaneous Findings in Hematolymphoid Neoplasms: An Observational Study
title_full_unstemmed Mucocutaneous Findings in Hematolymphoid Neoplasms: An Observational Study
title_short Mucocutaneous Findings in Hematolymphoid Neoplasms: An Observational Study
title_sort mucocutaneous findings in hematolymphoid neoplasms: an observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506838/
https://www.ncbi.nlm.nih.gov/pubmed/37727568
http://dx.doi.org/10.4103/idoj.idoj_438_22
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