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DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?

Hepatotoxicity is a frequent complication during maintenance therapy of acute lymphoblastic leukemia (ALL) with 6-mercaptopurine and methotrexate. Elevated levels of methylated 6-mercaptopurine metabolites (MeMP) are associated with hepatotoxicity. However, not all mechanisms are known that lead to...

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Detalles Bibliográficos
Autores principales:	Harju, Tekla, Hurme-Niiranen, Anri, Suo-Palosaari, Maria, Nygaard Nielsen, Stine, Hinttala, Reetta, Schmiegelow, Kjeld, Uusimaa, Johanna, Harila, Arja, Niinimäki, Riitta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506908/ https://www.ncbi.nlm.nih.gov/pubmed/37138020 http://dx.doi.org/10.1038/s41397-023-00303-0

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