Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH

Accumulation of lipotoxic lipids, such as free cholesterol, induces hepatocyte death and subsequent inflammation and fibrosis in the pathogenesis of nonalcoholic steatohepatitis (NASH). However, the underlying mechanisms remain unclear. We have previously reported that hepatocyte death locally induc...

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Detalles Bibliográficos
Autores principales: Itoh, Michiko, Tamura, Atsushi, Kanai, Sayaka, Tanaka, Miyako, Kanamori, Yohei, Shirakawa, Ibuki, Ito, Ayaka, Oka, Yasuyoshi, Hidaka, Isao, Takami, Taro, Honda, Yasushi, Maeda, Mitsuyo, Saito, Yasuyuki, Murata, Yoji, Matozaki, Takashi, Nakajima, Atsushi, Kataoka, Yosky, Ogi, Tomoo, Ogawa, Yoshihiro, Suganami, Takayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506914/
https://www.ncbi.nlm.nih.gov/pubmed/37725372
http://dx.doi.org/10.1084/jem.20220681

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