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A systematic review of the role of clozapine for severe borderline personality disorder
RATIONALE: Clozapine is a unique medication with a potential role in the treatment of severe borderline personality disorder (BPD). OBJECTIVES: The review examines the effectiveness of clozapine as a medication for management for severe BPD with high risk of suicide, violence or imprisonment, and ai...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506937/ https://www.ncbi.nlm.nih.gov/pubmed/37572113 http://dx.doi.org/10.1007/s00213-023-06431-6 |
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author | Han, Joshua Allison, Stephen Looi, Jeffrey C.L. Chan, Sherry Kit Wa Bastiampillai, Tarun |
author_facet | Han, Joshua Allison, Stephen Looi, Jeffrey C.L. Chan, Sherry Kit Wa Bastiampillai, Tarun |
author_sort | Han, Joshua |
collection | PubMed |
description | RATIONALE: Clozapine is a unique medication with a potential role in the treatment of severe borderline personality disorder (BPD). OBJECTIVES: The review examines the effectiveness of clozapine as a medication for management for severe BPD with high risk of suicide, violence or imprisonment, and aims to help guide clinical practice in managing severe BPD. METHODS: A database search of the terms “Clozapine” AND “BPD”; “Antipsychotics” AND “BPD”; “Clozapine” AND “Borderline Personality Disorder”; and “Antipsychotics” AND “Borderline Personality Disorder” were performed in CINAHL, Cochrane Library, Embase, Medline, PsychINFO, PubMed, and Web of Science. Full-text articles of clinical clozapine use for BPD were included for review. RESULTS: A total of 24 articles consisting of 1 randomised control trial, 10 non-controlled trials, and 13 case reports were identified. Most of the studies reported benefits from clozapine when used for severe BPD. Many of the studies focused on clozapine use in BPD patients at high risk of suicide. Results from these non-controlled and case reports support the use of clozapine in patients with severe BPD at high risk of suicide. CONCLUSION: There may be a role for clozapine in treating severe treatment refractory BPD, especially for those patients at high risk of suicide and frequent hospitalisations. |
format | Online Article Text |
id | pubmed-10506937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-105069372023-09-20 A systematic review of the role of clozapine for severe borderline personality disorder Han, Joshua Allison, Stephen Looi, Jeffrey C.L. Chan, Sherry Kit Wa Bastiampillai, Tarun Psychopharmacology (Berl) Review RATIONALE: Clozapine is a unique medication with a potential role in the treatment of severe borderline personality disorder (BPD). OBJECTIVES: The review examines the effectiveness of clozapine as a medication for management for severe BPD with high risk of suicide, violence or imprisonment, and aims to help guide clinical practice in managing severe BPD. METHODS: A database search of the terms “Clozapine” AND “BPD”; “Antipsychotics” AND “BPD”; “Clozapine” AND “Borderline Personality Disorder”; and “Antipsychotics” AND “Borderline Personality Disorder” were performed in CINAHL, Cochrane Library, Embase, Medline, PsychINFO, PubMed, and Web of Science. Full-text articles of clinical clozapine use for BPD were included for review. RESULTS: A total of 24 articles consisting of 1 randomised control trial, 10 non-controlled trials, and 13 case reports were identified. Most of the studies reported benefits from clozapine when used for severe BPD. Many of the studies focused on clozapine use in BPD patients at high risk of suicide. Results from these non-controlled and case reports support the use of clozapine in patients with severe BPD at high risk of suicide. CONCLUSION: There may be a role for clozapine in treating severe treatment refractory BPD, especially for those patients at high risk of suicide and frequent hospitalisations. Springer Berlin Heidelberg 2023-08-12 2023 /pmc/articles/PMC10506937/ /pubmed/37572113 http://dx.doi.org/10.1007/s00213-023-06431-6 Text en © Crown 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Han, Joshua Allison, Stephen Looi, Jeffrey C.L. Chan, Sherry Kit Wa Bastiampillai, Tarun A systematic review of the role of clozapine for severe borderline personality disorder |
title | A systematic review of the role of clozapine for severe borderline personality disorder |
title_full | A systematic review of the role of clozapine for severe borderline personality disorder |
title_fullStr | A systematic review of the role of clozapine for severe borderline personality disorder |
title_full_unstemmed | A systematic review of the role of clozapine for severe borderline personality disorder |
title_short | A systematic review of the role of clozapine for severe borderline personality disorder |
title_sort | systematic review of the role of clozapine for severe borderline personality disorder |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506937/ https://www.ncbi.nlm.nih.gov/pubmed/37572113 http://dx.doi.org/10.1007/s00213-023-06431-6 |
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